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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Science and goodwill meet drought-stricken communities

2016-03-02

“Everyone should contribute to the delivery of clean water to every individual,” says UFS researcher.

The drought in South Africa has impacted the country in many ways. Apart from its economic and environmental implications, the drought also has social implications, leaving some communities without water.

Since 21 January 2016, the Department of Water and Sanitation (DWS) is working together with the Department of Microbial, Biochemical, and Food Biotechnology at the University of the Free State. Dr Mariana Erasmus, post-doctoral fellow in the department, was appointed to lead a project for disinfecting tankered water supplied by the DWS to communities without water in the Qwaqwa area - which falls under the Maluti-a-Phufung Local Municipality.

She is working on the project with Robbie Erasmus from BioSense Solutions and Martin Bambo from DWS. A total of 53 trucks, 91 tanks, and 420 500 litres of water was disinfected so far, using sodium hypochlorite. “This is standard practice around the world,” Dr Erasmus said.

The work done by the UFS and DWS, who is monitoring the water quality as well as the process of water delivery, is very important. Disinfecting the trucks used to deliver water to drought-stricken communities decreases the formation of biofilm inside the tanks. “The biofilm could contain harmful bacteria such as E-coli. It is important to note that this is mostly the result of secondary pollution, since the water quality from the source where it was taken from, proved to be good. Drinking water with this harmful bacteria that has not been properly managed, can lead to health issues in humans when consumed,” Dr Erasmus said.

The Department of Microbial, Biochemical, and Food Biotechnology, interacting with the DWS on several water-related issues, volunteered to get involved in the project. They strongly believe that everyone should contribute to the delivery of clean water to every individual.

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