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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

University community join hands in the walk for peace and justice
2016-03-02

Description: Prayer walk Callie Human Centre Tags: Prayer walk

The Campus Ministries Forum and South African Council of Churches (Free State) have organised a walk for peace and justice from the Main Building to the Callie Human Centre on the Bloemfontein Campus of the University of the Free State (UFS) on Tuesday 1 March 2016. This walk was followed by a prayer meeting at the Callie Human Centre.

Pastors from the Campus Ministries Forum of the South African Council of Churches (Free State) led a group of more than 350 students and staff in praise and worship, followed by prayers in English, Afrikaans, and Sesotho.

A significant gesture at the event was the church leader’s plea for peace and solutions for the conflict at the UFS.

Bishop Monty Mabale, Chairperson of the South African Council of Churches, read an extract from the declaration compiled by the pastors ministering to staff and students at the UFS.

“We are saddened by the violence and vandalism that took place on and off campus.  We understand that there are many reasons for frustration and anger, which lead to tensions at the end of last year and again now. We also understand that there are different perspectives on these developments and the complexities underlying to this. However, we cannot agree with the hate speech, the continuous blaming of others, the instigation of violence, and the damage being caused to this precious institution and its commitment to the ideal and practices of reconciliation and a proper education for every student.

“Because we believe in the justice and mercy of God in Christ, let us seek His justice in a compassionate way. Let us resolve to glorify his name in the way we enter into dignified discussions when addressing those matters we perceive to be injustices, and seek for solutions. Let us be critical of our own biased perceptions, opening ourselves to the practice of listening to the viewpoints of others and learning from each other, while discerning the will of God in our society together,” Bishop Mabale said.

The forum and council also wrote a special prayer for UFS students, staff, parents, and management:

Our Father in Heaven
•    You have created us all as unique, special people, each with a great destiny.
•    You have an awesome plan for our University, and value every person working and studying here.
•    We have not respected Your heart and opinion of everyone on campus, and so we have sinned against You.
•    Forgive us where we did not follow Your example of reconciliation, restoration, and forgiveness through the blood of Christ, Your Son, on the cross. We need You to show us what You expect of us: grace, mercy, respect, and tolerance for one another from a place of gratefulness and humility.
•    We are grateful for the opportunity and honour You have given us to be involved in this institution.
•    We repent and accept afresh Your commandment to love You and to love our neighbour as we love ourselves.
•    You are saying to us: “For I know the plans I have for you," declares the LORD, "plans to prosper you and not to harm you, plans to give you hope and a future.” We, as an institution, believe and receive this promise You gave to us.

In Jesus Name we pray,
Amen.

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