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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Giraffe research broadcast on National Geographic channel
2016-03-09

Description: Giraffe research  Tags: Giraffe research

A documentary focusing on the latest and most interesting research about giraffes was recently broadcasted on National Geographic. Dr Francois Deacon from the UFS Department of Animal, Wildlife and Grassland Sciences and the team of researchers working with him, were first in the world to equip giraffes with GPS collars, and to conduct research on them.

Research by Dr Francois Deacon, from the UFS Department of Animal, Wildlife and Grassland Sciences, involving the equipping of giraffes with GPS collars, was broadcast this week as part of a documentary (4 March 2016 and subsequent weeks) on National Geographic (Channel 182). The documentary is the first of two on his team's research.

Dr Deacon and the team of researchers working with him were the first in the world to equip giraffes with GPS collars, and to conduct research on this initiative. The group of researchers can now follow the animals night and day by means of the GPS collars, while monitoring their movements from a distance on a computer screen and seeing the world from a giraffe's perspective.

“The documentary focuses on the latest and interesting information about our research in different countries,” Dr Deacon said. Besides their local research on giraffes, he and his team also assist in other projects and research in Namibia, Botswana, Zambia, Kenya, the Democratic Republic of the Congo, and Uganda.

“There is much to learn from the documentary,” Dr Deacon said. Interesting facts from their research include herd interactions by individuals towards each other, bulls versus bulls, and cows versus calves. In the documentary, the viewer can also learn how giraffes use thermoregulation, their tongues, and roaming areas and distances; peculiar behaviour such as feeding on bones and soil; bulls fighting; how and when giraffes drink water; and the conservation and management of giraffes.
 
Focus is also placed on the manner in which the latest research plays a role in the better understanding of the animals.
 
According to Dr Deacon, this is the first documentary to focus on giraffe research on such a large scale. Marco Polo Films from Terra Mater are contracted by National Geographic to produce nature films – this was the hundredth nature film produced by them.
 
“There has never before been such a production about giraffes. It also attracted huge interest and reaction overseas, which will provide great exposure for our research and for the UFS.
 
“We believe that the media involvement will provide much more exposure to giraffes, which is a good thing, since they are facing extinction in Africa. The exposure can, in itself, lead to new research and has already started attracting international students to the UFS,” Dr Deacon said.
 
The second documentary will follow later this year. Iniosante, a film team from Texas, USA, is producing this film, which focuses on the extinction of giraffes. It is the same team responsible for the production Last of the Longnecks.



Additional resources:


-    Last of the Longnecks (trailer)
-    Giraffe – Up high and personal (National Geographic video)
-    Giraffe: African Giant (National Geographic video)
-    Giraffe – Up high and personal (article)

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