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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Council approves a new Language Policy

2016-03-11

The Council of the University of the Free State (UFS) approved a new Language Policy with an overwhelming majority during its meeting held on the Qwaqwa Campus today (11 March 2016).

In the newly approved policy, the university commits to embed and enable a language-rich environment committed to multilingualism, with particular attention to Afrikaans, Sesotho, isiZulu, and other languages represented on the three campuses situated in Bloemfontein and Qwaqwa.

Based on the core values of inclusivity and multilingualism, the following principles in the newly approved policy were approved by the Council:

English will be the primary medium of instruction at undergraduate and postgraduate level on the three campuses situated in Bloemfontein and Qwaqwa.
Multilingualism will be supported among other activities by an expanded tutorial system especially designed for first-year students.
In particular professional programmes such as teacher education and the training of students in Theology who wish to enter the ministry in traditional Afrikaans speaking churches, where there is clear market need, the parallel medium English-Afrikaans and Sesotho/Zulu continues. This arrangement must not undermine the values of inclusivity and diversity endorse by the UFS.
The primary formal language of the university administration will be English with sufficient flexibility for the eventual practice of multilingualism across the university.
Formal student life interactions would be in English, while multilingualism is encouraged in all social interactions.

“This is a major step forward for the UFS. I commend Council for their constructive and positive manner in which the discussion took place,” says Judge Ian van der Merwe, Chairperson of the UFS Council.

The university furthermore committed in the newly approved policy to:

Ensuring that language is not a barrier to equity of access, opportunity and success in academic programmes or in access to university administration.
Promoting the provision of academic literacy, especially in English, for all undergraduate students.
Ensuring that language is not used or perceived as a tool for social exclusion of staff and/or students on any of its campuses.
Promoting a pragmatic learning and administrative environment committed to and accommodative of linguistic diversity within the regional, national and international environments in which the UFS operates.
Contributing to the development of Sesotho and isiZulu as higher education language within the context of the needs of the university’s different campuses.
The continuous development of Afrikaans as an academic language.
Recognising and promoting South African Sign Language and Braille.

Today’s approval of a new policy comes after a mandate was given to the university management on 5 June 2015 by Council to conduct a review of the institutional Language Policy through a comprehensive process of consultation with all university stakeholders. A Language Committee was subsequently established by the University Management Committee (UMC) to undertake a comprehensive review of the parallel-medium policy, which was approved by Council on 6 June 2003. The committee also had to make recommendations on the way forward with respect to the university's Language Policy. During its meeting on 4 December 2015, Council adopted guidelines from the report of the Language Committee regarding the development of a new policy for the university.

The newly approved Language Policy will be phased in as from January 2017 according to an Implementation Plan.

Released by:
Lacea Loader (Director: Communication and Brand Management)
Email: news@ufs.ac.za

Related articles:

http://www.ufs.ac.za/templates/news-archive-item?news=6567 (26 November 2015)
http://www.ufs.ac.za/templates/news-archive-item?news=6540 (28 October 2015)
http://www.ufs.ac.za/templates/news-archive-item?news=6521 (20 October 2015)
http://www.ufs.ac.za/templates/news-archive-item?news=6469 (30 August 2015)
http://www.ufs.ac.za/templates/news-archive-item?news=6444 (25 August 2015)

Released by:
Lacea Loader (Director: Communication and Brand Management)
Telephone: +27(0)51 401 2584 | +27(0)83 645 2454
Email: news@ufs.ac.za | loaderl@ufs.ac.za
Fax: +27(0)51 444 6393

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