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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Arment-My-Nie proved what a time it is to be alive at the 2016 Stagedoor
2016-03-15

Description: 2016 03 KL Stagedoor Tags: Stagedoor

2016 has been nothing short of events that have left students singing the phrase, “What A Time To Be Alive!” This year’s Stagedoor theme had first-year groups re-enacting some of the most memorable times of 2016 and even far into the future.

On 12 March 2016, the show continued with the newly adopted format which was initiated last year, whereby residences are coupled together. With all teams being entered into the finals round, this can be seen as a victory for all, as the crowds of students and parents had the opportunity to see all pairs perform.

Kovsie Church, on the Bloemfontein Campus of the University of the Free State, was packed wall-to-wall with fans and supporters who were high in anticipation of the never-seen-before performances. This resulted in even more excitement for audiences and a tight competition for the residences.

With the theme already set out, the show began to roll, and audiences were enticed with each performance. Audiences experienced the tongue-in-cheek wit of performers, as many scripts had underlying references which left viewers roaring with laughter.

Only three groups could, however, walk away with the top spots. Karee and Arista were third, with Sonnedou and Villa Bravado coming out second, and the trophy was taken by Armentum and Vergeet-My-Nie.

This year, the Arts and Culture office of the Student Representative Council introduced additional categories to the competition. The winners were:

  • McDonalds Jingle – Legatum and NJ van der Merwe

  • Best Actor – Bernie Neser

  • Best Actress – Maynie Knoetze

  • Best Incorporated Theme – Legatum and NJ van der Merwe

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