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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Arts and Science collaborate in creating sustainable futures

2016-03-16

Creating a future where living green is the status quo: Dr Keith Armstrong
Photo: Lihlumelo Toyana

In creating partnerships across disciplines, mankind gains a deeper understanding of how to create the future. This is the premise upon which Dr Keith Armstrong bases his research and experimental art. Dr Armstrong is an Australian Hybrid Media artist and a Senior Research Fellow at Queensland University of Technology in Australia.

Artists that make things happen

“My journey has shifted from an artist that makes things to an artist that makes things happen,” he said at the New Futures: Innovations in Arts and Science public talk recently at Oliewenhuis Art Museum. The talk, organised by the Johannes Stegmann Art Gallery, was part of a series of artistic projects presented by the Programme for Innovation in Arts and Development (PIAD). This initiative is spearheaded by the UFS and Vrystaat Arts Festival, kindly supported by The Andrew W. Mellon Foundation.

Dr Angus Hervey – an Australian writer, technologist and science communicator– was also a speaker at the event. Dr Hervey is a co-founder of Future Crunch, a platform for intelligent, optimistic thinking about the future. He strongly shares Dr Armstrong’s passion and viewpoints.

Dr Armstrong’s work is motivated by social and ecological justice. His non-traditional research and more than 60 artworks serve to evoke audiences to create sustainable futures.

Building the future

Dr Armstrong is in the process of making “things happen” in informal settlements across the Free State by means of his Re-Future project. The project brings together sustainability, community development, and creative action. It moves away from conventional art practices and instead offer a platform to rethink and therefore re-future our practices of sustainability.

The Re-Future project has been initiated through a collaboration between the Johannes Stegmann Art Gallery, the UFS Centre for Development Support (CDS) and Qala Phelang Tala (QPT) and the Vrystaat Art Festival.

According to Anita Venter, a lecturer at CDS and founder of QPT, empowerment is at the centre of the artist-initiated, yet community-controlled project. “It gives a new direction and new hope to the community,” she said.

For more information
Angela de Jesus, dejesusav@ufs.ac.za or +27(0)51 401 2706

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