Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Medical students enrich lives through community service project
2016-03-18

Description: 2016 03 18 Outreach  Tags: 2016 03 18 Outreach

A group of third-year medical students organised a fun day for Ons Kinderhuis as part of their community service project.

As part of their curriculum, third-year MBChB students are required to complete a community service project in collaboration with a specific NGO in Bloemfontein. Not only do these projects serve an academic requirement, but also echo the spirit of service and compassion emblematic of the Human Project of the University of the Free State (UFS).

 

One group of students chose to pour their time and care into Ons Kinderhuis–home to 100 children with special needs. Since their involvement, these medical students have helped improve the home’s facilities and also hosted various fun days for the staff and children.

 

The latest fun day was celebrated on Saturday 12 March 2016. The festivities were kicked off in the morning by a game of soccer using the brand-new goal posts recently built by the medical students. It was difficult to decide who were more excited – the children or the staff – when some of the Cheetah rugby players joined the event. A slippery slide came in handy to wash off sticky hands and mouths and for little bodies with lots of energy the jumping castle was a perfect answer. Faces were painted and a banner created while music and the smell of the braai floated into the autumn air.

 

“I couldn't help but be proud of my team and thankful for this opportunity,” said Willem Potgieter, one of the student volunteers. Seeing the smiles on the children’s faces made it all worthwhile. “It was truly a humbling and a great learning experience for each and every one of us,” Willem said.

 

This group of medical students consist of Burger Oosthuizen, Marié Engelbrecht, Lourens Badenhorst, Dirki Wessels, Roodt Ehlers, Shirley-Louise du Plessis, Mariet Geldenhuys, Louise-Mari Zietsman and Willem Potgieter.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept