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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Osaka University in Japan joins forces with UFS to discuss SA and Africa

2016-03-23

Yani Karavasilev of Osaka University speaking about political stability and Foreign Direct Investment in the Southern African Development Community on day-2 of the joint conference between Osaka University and the University of the Free State.
Photo: Dr Marina da Silva

Recently, international delegates convened for the annual Osaka University-University of the Free State (UFS) Conference to discuss issues that affect Africa. This high-profile conference was hosted by the UFS Department of Political Studies and Governance from 22-23 February 2016. The event focused its attention on the state of South Africa (SA) as well as conflict resolution on the African continent.

Topics of discussion

Scholars and policymakers proceed to map out the political, economic, social, and educational trajectory of SA and the African continent. Some of the topics of discussion included SA politics, democracy, economy, foreign policy, race, education, and peace. Delegates also looked at foreign direct investment in the Southern African development community and organisations such as the United Nations and the African Union.

Entangled in turmoil

At the conference, Prof Virgil Hawkins of the Osaka School of International Public Policy, (Osaka University) presented a paper entitled: The role of the local media in Burundi’s 2015 coup attempt. In his presentation, Prof Hawkins analysed the impact made by Radio Publique Africaine, Renaissance, Isanganiro, and Bonesharadio stations during the conflict. Had it not been for these private radio stations, the events leading to, during, and after the coup would not have received international coverage.

Prof Hawkins explained that prior to the coup, “key private radio representatives were called to Musaka military camp” by former intelligence chief, Major General Godefroid Niyombare. He informed them about the coup plot and urged them to report on it. The government in turn accused the independent media of colluding with the coup conspirators. As a result, the radio stations were attacked, coerced to go off-air, and subsequently destroyed. Despite overt efforts by the state to suppress the media’s freedom of expression, it did not succeed.

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