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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Book Prize for Distinguished Scholarship awarded to Dr Christian Williams

2016-03-24

Prof Jonathan Jansen, Vice-Chancellor and Rector of the University of the Free State and Dr Christian Williams, senior lecturer at the UFS Department of Anthropology.
Photo: Johan Roux

When Dr Christian Williams moved from the United States to Namibia in January 2000 as part of the WorldTeach volunteer programme for teachers, he had not anticipated an award-winning piece of scholarship in his future. It was during these visits to Namibia, though, that the seeds for his highly-acclaimed book were sewn.

While volunteering at the St. Therese Secondary School in Tses at that time, Dr Williams – now a senior lecturer at the University of the Free State (UFS) Department of Anthropology – became acquainted with some of the school’s alumni. The stories these individuals started sharing with him soon revealed personal histories of exile and violence by fellow SWAPO (South West Africa People’s Organization) members.

These experiences ultimately resulted in Dr Williams’ book, National liberation in postcolonial southern Africa: a historical ethnography of SWAPO’s exile camps, published last year. Due to the book’s literary impact, the university awarded Dr Williams the UFS Book Prize for Distinguished Scholarship on Friday 19 February 2016. Dr Williams is the second academic to be awarded this prize.

Politics of the past

In the 1960s, Namibians mobilised and retaliated against colonial rule under the liberation movement known as SWAPO. This created political tension which resulted in the flight of many SWAPO members to exile camps administered by the party.

“Over its three decades in exile, SWAPO was responsible for the welfare of roughly 60 000 Namibians. This was about 4% of the total Namibian population at independence – most of whom lived in camps,” says Dr Williams. The research originally used as a basis for his doctoral thesis was subsequently developed into this prize-winning book.

Advancing the Human Project

“It’s an honour to receive recognition from the university; it means that they value the kind of work that I am doing. I think it’s great for universities to have such prizes,” Dr Williams says.

Supporting the UFS Human Project, Dr Williams will donate a portion of the R25 000 prize money towards the UFS Student Bursary Fund Campaign, as well as the school in Namibia.The rest will subsidise the purchase of the book for distribution to libraries and as gifts.

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