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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Louzanne Coetzee breaks 16-year-old world record
2016-03-24

Description: Louzanne Coetzee kampioen Tags: Louzanne Coetzee kampioen

Louzanne Coetzee (left) running the 5 000 m at the Nedbank National Championships at the Free State Athletics stadium with her guide, Khotatso Mokone (right)
Photo: Celeste Klopper Photography

Whether it’s the 5 000 m or the 1 500 m, Louzanne Coetzee is breaking records in all her races. Fans of the University of the Free State (UFS) student were elated at her triumph with the 5 000 m T11 world record at the Nedbank National Championships for the Physically Disabled on Wednesday 23 March 2016.

The record, which has stood for 16 years, was shattered by Coetzee’s stellar 19:17.06 performance. Sigita Markeviciene’s long-standing mark of 20:05.81, set at the 2000 Paralympics in Sydney, was bettered by 48.75 seconds when Coetzee and her guide, Khotatso Mokone, sprinted hand in hand past the finish line. 

Coetzee’s coach is as elated as the world-class athlete’s fans over her officially becoming the first totally blind female to clock sub-20 minute in the 5 000 m. "I am proud and grateful. She earned it through and through. She worked hard for this,” said Rufus Botha.

The experience was a surreal one for Coetzee. “It was unreal but it is exciting to be the fastest in Africa and the world. I could not have done it without the support system that I have,” she said.

"I have seldom met a student with the character and humanity of Louzanne Coetzee; she represents the best of campus and country, and is a stunning example of what we canal  achieve despite the great challenges of the present," said Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS.

New African record holder

Two days before breaking the 5 000 m world record, Coetzee set a new African record in the 1 500 m. She lowered the mark from 5:27:21 to 5:18:44, which placed her at the number nine spot in the world.

On Friday 18 March 2016 Coetzee had broken her own South African record when she ran 5 000 m in less than 20 minutes at the Free State Championships. However, the race is not an official (International Paralympic Committee) meeting, and hence remains unofficial.

What’s next?


The gold medallist is currently preparing for the Athletics Grand Prix to be held in Switzerland in May for which she is raising funds. If she is selected by SASCOC (South African Sports Confederation and Olympic Committee), her next stop is the Paralympic Games in Rio de Janeiro, which is just six months away.

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