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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Two Kovsies in SA Netball team for World Student Games
2016-04-18

Description: Lauren-Lee Read More Tags: Lauren-Lee Read More

Lauren-Lee Christians became the 12th Protea from the University of the Free State in 2015. She will play for the South African Universities Netball team in America during July.
Photo: SASPA

Two students from the University of the Free State (UFS), Lauren-Lee Christians and Karla Mostert, were selected for the South African Universities Netball team.

The team, with eight Proteas in its ranks, will be in action at the World Student Games in Miami, USA, from 13 to 17 July 2016.

Among the criteria for selection is that participants should not be older than 27 years in 2016, and they should have been students last year.

The South Africans, who came in second during the inaugural tournament in Cape Town four years ago, will be difficult to beat this time. A total of 12 countries will compete for the title of student champions.

Mostert part of previous successful team

Mostert was one of five Kovsies playing for this team in 2012, when South Africa lost 49-53 to Britain in the final. This came after the score was even at the end of regular play.

Mostert was also one of the two best players for the Proteas at the World Cup last year. Christians just missed out, and had to be content with being a non-travelling substitute after she became the 12th Protea of the UFS earlier in 2015.

Four from UFS in Cucsa squad

Meanwhile, four other of their teammates - Rieze Straeuli, Tanya Mostert, Kgomotso Mamburu, and Alicia Puren - were included in a provisional squad of 15 players to compete for the South African student team at the Cucsa Games (Southern African Student Games). This squad will soon be reduced to the 12 players who will represent their country in Bulawayo, Zimbabwe, from 1 to 6 August.

No Protea can be selected for this student team. A fifth Kovsie, the goal shooter, Dénielle van der Merwe, was also selected for the initial squad, but had to withdraw due to a serious leg injury.


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