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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Meet our Council: Ndaba Ntsele – Inspiring entrepreneurs

2016-04-19

Mr Ntsele
Photo: Stephen Collett

To call Mr Ndaba Ntsele just a businessman seems like a bit of an understatement. The Executive Chairman and co-founder of Pamodzi Group Limited lives and breathes business, entrepreneurship, and wealth creation. He is also a member of the Council of the University of the Free State (UFS) since September 2013.

His greatest passion is entrepreneurship, and sharing his ideas of self-employment with young (and old) South Africans. “I preach self-employment wherever I go. Everyone knows that unemployment is a major problem in our country. However, people often expect the government or big corporations to provide them with jobs. I like to influence people to start thinking about working for themselves, thereby creating opportunities for employing others,” he says.

His entrepreneurial drive extends even to his time on the UFS Council. Now in his second term, Mr Ntsele has been well placed to get a sense of the kind of contribution the university and its students could make to South Africa, and even further afield.

“In addition to training students for all the other important industries in South Africa, I think the UFS is ideally situated to create agricultural entrepreneurs. The Free State is one of South Africa’s prime agricultural areas, after all. Food security is an issue worldwide, and it is an area in which we could make a real contribution by training food producers, food technologists, and agricultural specialists. In fact, I think the UFS could become the leading agricultural institution in the country.”

Being the best is something that he strives for continually, while high standards are not something he shirks. In fact, he believes that Council members should hold an institution accountable for maintaining the highest standards possible, whether it is in governance, financials, procurement, or any other areas of importance in an institution.

As the executive chairman of a multi-billion African-owned group with assets across the globe, Mr Ntsele does not have a great deal of free time. However, he enjoys sitting down with MBA students and graduates to share his views about entrepreneurship.

“If I can change their mind-set from ‘others must employ me’ to ‘I need to create my own employment’, then I will feel as if I have accomplished something,” he says.

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