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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS establishes a Postgraduate office
2007-07-18

The University of the Free State (UFS) will establish a postgraduate office that will serve as a one-stop service for the co-ordination of academic support services for postgraduate students.

According to the Director: Research Development at the UFS, Prof Frans Swanepoel, the primary purpose of the Postgraduate Office is to provide co-ordination and support services for postgraduate students and postdoctoral fellows, as well as academic staff across the University.

“Guided by values such as intellectual inquiry, innovation, collegiality, integrity and efficiency, the Postgraduate Office will seek to foster a challenging, inclusive and supportive environment for postgraduate teaching, learning, research and scholarship; and will strive to engage students in the vibrant life of a research university”, Prof Swanepoel said.

All sectors of the University, namely students, faculties and staff, stand to benefit from the establishment of this office. Amongst other benefits for these sectors, postgraduate students and postdoctoral research fellows will have their interests promoted in synergy with faculty and departmental facilities. On the other hand, the office will provide a critical resource to the faculties in the form of a single database of postgraduate students, postgraduate topics, supervisors and funding opportunities. Furthermore, it will serve as a useful resource and base for training and information for younger and less experienced staff members.

The establishment of this office will be undertaken in two phases. The first phase will focus on the most critical areas that will make an immediate impact and the second phase on those areas that are not as urgent.

Areas that will be prioritised include the appointment of a manager and co-ordination of stakeholders, the provision of information and communication, useful resources for the UFS, policy administration and monitoring, postgraduate supervisors’ facilitation, recruitment activities, advice and referral, and postgraduate scholarship and bursary management.

The less urgent components of the office will be the development and implementation of academic and professional support programmes, the formation of a research information commons to create an integrated learning environment for postgraduate students, and the development of a postgraduate association or a postgraduate students’ liaison committee to provide a recognised channel of communication between postgraduate students and the University authorities.

The Postgraduate Office will form a vital component of the Directorate Research Development (DRD) at the UFS because of its experience and a noteworthy track record with regard to a facilitative and co-ordinating role that would be essential for the office.

“Establishing the Postgraduate Office as part of the Directorate would give the Centre the necessary links to the research-related issues that are important to most of the postgraduate students at the UFS. Of essential importance will be the linkages with the full spectrum of Strategic Clusters”, Prof Swanepoel explained.

“An important component of the Postgraduate Office will be related to international students and international opportunities for UFS postgraduate students. As the Office for Internationalisation has similarly been placed within the Directorate, the work of the Postgraduate Office will be facilitated by similar placement within the same Directorate”, he concluded.

Media release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@mail.ufs.ac.za  
18 July 2007
 

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