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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Research conducted on economic impact of recent international soccer and rugby matches for Bloemfontein
2004-09-09

The Centre for Development Support at the University of the Free State (UFS) recently conducted a survey on the economic impact of the international soccer and rugby games that were played in Bloemfontein earlier this year.

The research focused on the soccer match between Bafana Bafana and the Cape Verdic Isle and the rugby match between the Springboks and Ireland .

“The survey was done as a result of a research agenda about local economic development in Bloemfontein ,” said Dr Lochner Marais, researcher at the centre.

“We conducted the research by doing 402 interviews with soccer supporters and 376 interviews with rugby supporters from outside Bloemfontein ,” said Dr Marais.

The centre distributed questionnaires, collecting the following information on the soccer and rugby supporters: their age, gender and origin, the number of nights spend in Bloemfontein , their household expenditure in Bloemfontein and their rating on the quality of service.

“It is estimated that 10 800 soccer supporters and 27 000 rugby supporters came from outside Bloemfontein . Of the rugby supporters 14,4% were female and 85,6% were men. For the soccer international the percentage was 33% females and 67% males,” said Dr Marais.

The highest number of people who came to watch the soccer game in Bloemfontein (35,8%) was from the Northern Free State . The rugby supporters mainly came from Gauteng (21,8%) and the Northern Free State (18%).

When visiting Bloemfontein soccer supporters spend R912 per household, whilst rugby supporters reached deeper in their pockets and spent R1 807 per household.

“The survey indicated that the two international matches resulted in approximately R58 million been spent in Bloemfontein . Rugby supporters were accountable for the largest part (R48 787 205) spent. The largest chunk of the money spent was on accommodation (R14 593 279). On average soccer and rugby supporters from outside Bloemfontein spent 1,4 and 1,9 nights in Bloemfontein ,” said Dr Marais.

Rugby and soccer supporters were also asked to rate the quality of service received from amongst others hotels, guest houses, restaurants, and transport and entertainment facilities. Soccer supporters rated their satisfaction with services higher as rugby supporters. The rugby supporters gave the services at hotels a 3,9 rating, whilst soccer supporters awarded 4,6 rating out of a possible five.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
9 September 2004
 

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