Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Council confirms decision to integrate student residences

2007-09-14

At its quarterly meeting held today (Friday, 14 September 2007) the Council of the University of the Free State (UFS) confirmed the decision taken at its previous meeting that the student residences of the UFS should be racially integrated.

The decision was taken with an overwhelming majority with only one vote against it and will be implemented in January 2008.

The Council tabled and noted the resolution of the Convocation of 11 September 2007 concerning the Council’s initial decision of 8 June 2007 and urged the management to continue to be sensitive, empathetic and inclusive in dealing with the concerns and views of all stakeholders.

The Council also gave all interested parties the assurance that any suggestions that could assist in the successful implementation of its decision would be considered and called once again on all stakeholders to make proposals to the management of the UFS so as to ensure a well-managed process of integration and managing diversity in residences.

In this regard it welcomed the suggestion made by the alumni of the UFS for the introduction of a Diversity Scorecard for residences which would include a multi-dimensional range of indicators and incentives for residences. This could include the diversity profile of a residence, the academic performance of the students in a residence, inter-residence activities and community service projects launched by students.

According to the Rector and Vice-chancellor of the UFS, Prof. Frederick Fourie, the Council hereby also restated the educational motive for the integration of residences, which meant that from an educational point of view, students who had the knowledge and skills to manage diversity would have a distinct advantage in the workplace and in life.

“Today’s decision is a major step forward for the Council and the UFS to achieve a broad consensus around the promotion of diversity at the UFS and in its residences, as the institution has always been committed to giving the best education to students in a diverse and non-racial environment. I would like to call on current students, prospective students, parents, alumni and other stakeholders to make this work in the best interests of the university and its students,” Prof. Fourie said.

He added that the UFS had established several task teams comprising staff and students to implement the Council’s decision of 8 June 2007 and that much work had already been done to identify critical areas and tasks ahead of implementation in January 2008.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
14 September 2007

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept