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12 December 2024 | Story AndrƩ Damons | Photo AndrƩ Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Meet our Council: Kgotso Schoeman - I’m not afraid of challenges
2016-04-21

Description: Kgotso Schoeman  Tags: Kgotso Schoeman

Mr Kgotso Schoeman
Photo: Stephen Collett

It’s not often that someone is asked a favour by the MEC of Education. However, when it does happen, it is a sign that he has full confidence in you and your abilities. This is exactly what happened to Mr Kgotso Schoeman, one of the Council members of the University of the Free State (UFS).

Mr Schoeman, who was approached by the MEC of Education in the Free State, Mr Tate Makgoe, to serve on the UFS Council, has been involved with the Kagiso Trust for the past 20 years, and now serves as the CEO of Kagiso Capital. The Kagiso Trust was established in May 1985 by anti-apartheid activists, including Archbishop Desmond Tutu, Dr Beyers NaudƩ, and Prof Jakes Gerwel, in order to channel funds for the promotion of the struggle against apartheid, and for the upliftment and empowerment of communities. Today, education plays a leading role in the activities of the trust.

Mr Schoeman is now serving his second term on the UFS Council.  At the start of his term, he expressed a particular interest in learning more about the inner workings of universities, and the UFS in particular.  He believes the past two years, have been very informative in this regard.

"I have been very impressed with the academic performance of the UFS, and I have learned a lot about university governance and management during this time.  I do think, however, that there is a lot of room for improvement with regard to transformation at the UFS, especially at academic staff level," he says.

One of the issues that he has become aware of over the past two years, and which concerns him greatly, is the relationship between higher education institutions and the Department of Higher Education and Training.  It relates to another matter of concern: how higher education should be funded in South Africa.

"These are issues I raise at every Council meeting, because I feel these points are important not only for the future of the UFS, but for all higher education institutions in the country," he says.

When it comes to hobbies, Mr Schoeman loves reading. However, it is not fiction that interests him, but rather books on leadership and the changes experienced by today’s society. ā€œIn one of the educational programmes we offer, there are opportunities for people to discuss complicated topics, such as transformation. I find it fascinating to see how people can change their point of view in the course of these discussions.ā€

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