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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

We must rise again, says Dr Luescher
2016-05-04

Description: 2016 05 04 Dr Luescher sml Tags: 2016 05 04 Dr Luescher
Dr Thierry Luescher, Assistant Director of University of the Free State Directorate for Institutional Research and Academic Planning, was one of the guest speakers at the first TEDxUFS event of the year on the Bloemfontein Campus. Here he is explaining where the #movements started, and how to change the way we think. Photo: Marli du Plessis.

The student protests, known as the #MustFall movements, started on 9 March 2015, when students protested in a well-rehearsed manner at the Cecil John Rhodesstatue at the University of Cape Town. After this protest, students all over South Africa started their own movements from #OpenStellies to #SwartsMustFall, the latter happening on the Bloemfontein Campus of the University of the Free State (UFS) in March 2016. But, as Dr Thierry Luescher, Assistant Director of UFS Directorate for Institutional Research and Academic Planning, says: “We shall soon run out of #MustFalls. Maybe it is time that we rise again.”

The first TEDxUFS was held on Friday 15 April 2016 at the New Education Building on the Bloemfontein Campus of the UFS. Dr Luescher shone light on the way we look at hashtag movements. At the conference, he was one of the guest speakers who shared their perspectives on the theme of #ImpossibleIsNothing. The others were Ndumiso Hadebe, and Fezile Sonkwane.

Changing angles

No matter what the issue, whether it is on a campus or not, the same reaction can be expected by all: they burn things to get attention. In retrospect, this is our political culture. This is what we have been told to do if we need answers. There is a much faster and cheaper way to attract people’s attention: the hashtag movements, says Dr Luescher.

Stop the fire

He argues that we should stop burning down buildings and vandalising properties. What we need is people with intellect to use their words. We, as students, have to take back our voice. We need to stop this self-pitying, and take a stand.

Students have the power to change lives. We would be able to reach as many as 1.4 million people with our tweets or instagram accounts. According to Dr Luescher, the time for violence has come to an end.

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