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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Prof Van den Oever gives students a different perspective

2016-05-06

Description: Prof Van den Oever gives students a different perspective Tags: Prof Van den Oever gives students a different perspective

Prof Annie van den Oever from the Netherlands presented a series of guest lectures on media technologies to students of the Film and Visual Media Programme at the University of the Free State (UFS). Here from left is Chris Vorster, lecturer in Drama and Theatre Arts, Prof Van den Oever, and Dr Pieter Venter, Senior lecturer at Drama and Theatre Arts.
Photo: Jóhann Thormählen

She played a part in conceptualising the Film and Visual Media Programme at the University of the Free State (UFS), and sees film from a perspective different from most young South Africans.

According to Chris Vorster, lecturer of the UFS BA Honours degree in Film and Visual Media, this is one of the reasons why Prof Annie van den Oever’s visit is of such great value. The actor, who is a lecturer in Drama and Theatre Arts, believes it is important to expose his students to influences outside their normal experience.

Prof Van den Oever, an extraordinary professor at the UFS since 2011, presented a series of guest lectures on media technologies from 11-14 April 2016 at the Audio Visual Studio on the Bloemfontein Campus. She is a senior researcher for Film at the University of Groningen in the Netherlands, and an Associated Researcher for Film at Paris 1, Panthéon Sorbonne, in France.

Another milieu

“It is invaluable for students, in any field of study, to receive as many influences from the outside. Therefore, it is important to have someone here from another milieu and context. And academically, she is outstanding,” says Vorster.

Vorster’s students are also exposed to practical expertise from the industry in the country, not only academics.

Relationship with UFS

Prof Van den Oever says she usually visits the UFS twice a year. Her recent lecture series on media technologies was about the power of visual and film culture today, and how you can understand its powers. “Why strange effects work strongly and why the strange is inserted, because people respond strongly to them,” she says.

Prof van den Oever enjoys meeting new people, and often works with colleagues from the UFS on various projects. She also is full of praise for the management of the university. “It is great to work across cultures, and be part of a university in transition.”

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