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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Expansion to Physics building officially opened on Bloemfontein Campus

2016-05-06

The newly-opened addition to the Physics Building on the Bloemfontein Campus.
Photo: Charl Devenish

An extension to the Department of Physics at the University of the Free State (UFS) was officially opened on the Bloemfontein Campus on 20 April 2016.

“This started off about five years ago when we were talking about not having enough room for large classes. Prof Matie Hoffman suggested that we build a large lecture room on our parking space,” said Prof Hendrik Swart, Professor in the Department of Physics as he addressed guests at the official opening ceremony.

“A year later, we received a Sarchi Research Chair [South African Research Chairs Initiative] on Advanced and Luminescent Materials. We needed more office and laboratory space. The two ideas were combined and presented to the university’s senior management,” he added.

When the university was founded in 1904, Prof James Lyle was appointed to head up the Physics and Chemistry departments. Five years later, a single room was allocated for the Physics laboratory in the main building upon its completion. In 1947, the old Physics building was designed and constructed. Fast forward 69 years, the department has reached another milestone. Facilities accommodated by the expansion include a new telescope for astrophysics experiments, a basement for storing old equipment, as well as a sliding trap door which allows heavy goods to be elevated into the building from the ground floor. The telescope is one of the many unique features of the building given its capacity to expose graduate students to the basic techniques of radio astronomy, especially in light of the fact that the SKA (Square Kilometre Array) project which is in progress.

“Our department is extremely strong at this stage, and a bright future lies ahead,” said Prof Koos Terblans, the Head of Department. The opening also served to celebrate the 103 publications achieved by the department last year.

Dr Lis Lange, Vice-Rector: Academic is proud of the heights reached by the department to date. “The Department of Physics is undoubtedly one of the jewels in the crown of our university, and we are very proud of its developments. Universities are built on legacies, and they are also about change, which is what this department has been demonstrating.”

The expansions to the building with its top-class facilities, was constructed at a cost of R25 million – an infrastructure grant courtesy of the Department of Higher Education and Training.

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