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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Horse-riding therapy improves self-confidence in children
2016-05-10


This group of Honours students in Psychology at the University of the Free State was honoured with the best postgraduate Service Learning award at the prize-giving function of the Faculty of the Humanities. From the left are Adriana de Vries, Hershel Meyerowitz, Simoné le Roux, Wijbren Nell, Melissa Taljaard, and Gerán Lordan. Photo: Marizanne Cloete.

Horse-riding therapy helps to improve self-confidence in children, and changes their perception of themselves. It puts them in a totally new environment where they can be free of any judgement.

According to Wijbren Nell, who achieved his Honours degree in Psychology at the University of the Free State (UFS), this is the ideal therapy when working with children with disabilities. He said it was amazing to see how they developed.

He was part of a group of Honours students in Psychology who received the best postgraduate Service Learning award in the Faculty of the Humanities for their community project. In 2015, this project by Wijbren, Hershel Meyerowitz, Gerán Lordan, Melissa Taljaard, Simoné le Roux, and Adriana de Vries, was part of their module Community and Social Psychology. They were honoured at the Faculty’s prize-giving function on 15 April 2016.

Purpose of project

“Our purpose with the project was to demonstrate to the children that they could still accomplish something, despite their disabilities,” Wijbren said. The students work on a weekly basis with learners from the foundation phase of the Lettie Fouché School in Bloemfontein. Marie Olivier’s Equistria Therapeutic Development Trust serves as the site for the community project. She has a long standing partnership with the UFS.

Horse-riding and therapy

According to Wijbren, the idea was to stimulate the psychomotor functioning of the children, as well as to promote their psychological well-being. He said research has shown that there is incredible therapeutic value in horse-riding. In this specific case, it has improved the children’s self-confidence, as they may have a poor self-image as a result of their disabilities.

“At the beginning of the year, there was a girl who didn’t even want to come close to a horse, let alone getting onto the horse. We kept on trying, and, once she was on the horse, we couldn’t get her down. This was the amazing thing about the project,” said Wijbren.

Award a surprise

Wijbren said the award was a honour and surprise to his group. He was full of praise for Dr Pravani Naidoo, a lecturer in Psychology at the UFS, who coordinates the therapeutic horse riding project. “She has a tremendous passion for this project, and challenged us to think on our feet. She is a real inspiration.”

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