Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Johann swims his way to Olympics
2016-05-18


Johann van Heerden from the University of the Free State has qualified for the Paralympic Games in the swimming pool, and is now waiting to hear if he will be included in the South African team. Photo: Nadya van Heerden.

In the past couple of months, Johann van Heerden has been swimming his way to the Paralympic Games, and is still preparing as if he will be going to Rio de Janeiro.

The Kovsie swimmer, who will know whether he has been included in the Paralympic team in July 2016, feels his training is progressing well. The Olympics will be held in Brazil from 7 to 18 September 2016. If all goes well, this could be the first of several Olympics for the 20-year-old second-year Education student from the University of the Free State (UFS).

Dream year for Education student

Van Heerden (cerebral palsy), whose hero is the former Paralympic superstar Natalie du Toit, has had huge successes in the run-up to the 2016 Olympics. Among others, he was named the best senior swimmer at the Nedbank National Championships for the Physically Disabled in Bloemfontein in March 2016. At the South African Senior Championships in Durban in April 2016, he qualified for the Olympics in the 100 m breast-stroke with an A-qualifying time, and in the 50 m and 100 m freestyle with B-qualifying times.

Only three male swimmers to Olympics

However, he has to wait until the announcement of the South African Paralympic team, since only three male and three female swimmers will be selected. He will not be competing in another major event before the Olympics. “My short-term goal is to compete in this year’s Games, and, in the long term, I would like to reach even greater heights at the 2020 Games,” he said. Du Toit is an inspiration to him because “she was hard-working, and she had a lot of drive”.

Other students from CUADS also excel

At the above-mentioned National Championships, Van Heerden won a total of five gold medals (200 m medley, 100 m breaststroke, 50 m freestyle, 50 m breaststroke, and 200 m breaststroke) and one silver medal (100 m freestyle). Other students from the Center for Universal Access and Disability Support at the UFS also excelled.

Dineo Mokhosoa (cerebral palsy) won three gold medals (long jump, shot-put, and discus), while the athlete Louzanne Coetzee (blind) shattered the world record in the 5 000 m, as well as the Africa record in the 1 500 m. Juanré Jenkinson (cerebral palsy) won two silver medals (discus and shot-put) while Danie Breitenbach (blind) won two gold medals (800 m and 1500 m).

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept