Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

SA and Indonesia strengthen educational ties

2016-05-19

Description: Embassy of Indonesia Tags: Embassy of Indonesia

From the left were Prof Hussein Solomon, Senior Professor at the Department of Political Studies and Governance; Professor Ikrar Nusa Bhakti, Research Professor of the Indonesian Institute of Sciences; Suprapto Martosetomo, ambassador of the Embassy of Indonesia to South Africa; and Prof Theodor Neethling, Head of the Department of Political Studies and Governance.
Photo: Johan Roux

“Indonesia and South Africa share one common trait which is diversity,” were the opening remarks of Suprapto Martosetomo, ambassador of the Embassy of Indonesia to South Africa. The ambassador drew parallels between the two republics at a public lecture hosted by the Department of Political Studies and Governance at the University of the Free State Bloemfontein Campus on 10 May 2016.

Professor Ikrar Nusa Bhakti, Research Professor in the Indonesian Institute of Sciences, presented the lecture on “Managing Political Diversities: The Indonesian Experience.” He outlined the history of Indonesia’s political and economic development, political system, and government’s policy in dealing with political and economic challenges, as well as the lessons learned from its experience.

Diversity and governance
As is South Africa, Indonesia is a ‘rainbow nation’. Being the largest country in the Southeast Asia, it boasts a population of approximately 250 million people, 300 ethnic groups, and 650 local languages. However, despite such diversity, the nation has been united behind the motto of “unity in diversity”, which was adopted when Indonesia proclaimed its independence in 1945.

Indonesia and SA also bear similarities in terms of a multiparty parliamentary system. Their current Joko Widodo and our Jacob Zuma administrations are governed by policies including anti-corruption, economic prosperity, equity and equality, quality education and healthcare, and maintenance of security.

International relations
The two countries have a long-standing relationship since 1955 when the Asia-Africa conference was held in Bandung, Indonesia. The conference represented solidarity against colonisation.

Prof Hussein Solomon, Senior Professor at the UFS Department of Political Studies and Governance, attributes Indonesia’s success as a product of education and leadership - something South Africa could learn from..“Indonesia like SA has been struggling with how to balance social diversity, democracy, and a political system. Despite this, they have managed to develop a functioning democracy and a vibrant economy. They are one of the top 20 economies in the world, and by the year 2035 will be in the top seven economies in the world, according to the Goldman Sachs, report,” he said.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept