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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Faculty of Theology hosts expert on African Traditional Religion (ATR)

2016-05-20

Dr Nokuzola Mndende, Prof Fanie Snyman (Dean of the Faculty of Theology), and Dr Luvuyo Ntombana (Department Head: Religion Studies)

Dr Nokuzola Mndende, an acclaimed theologian, researcher, and practitioner of African Traditional Religion (ATR), is often called upon in the media to offer her expert opinion or participate in interfaith panel discussions. Thanks to an initiative from the postgraduate diploma class in the Faculty of Theology and the efforts of Dr Luvuyo Ntombana (Department Head: Religion Studies; Faculty of Theology), Dr Mndende accepted an invitation to present her paper, “From the periphery to the centre: African Traditional Religion in a democratic state”, on the Bloemfontein Campus of the University of the Free State (UFS). In his opening remarks, Dr Ntombana stated that he was heartened by his students’ desire to be “co-workers in knowledge production” by engaging with Dr Mndende.

Dr Mndende’s contention is that African Traditional Religion (ATR) was suppressed throughout colonial times, and, despite a 22-year-old democracy, continues to be moved to “beyond the periphery” by what she terms “spiritual subsets”; those who strive to amalgamate their African Traditional Religion rituals with the practices of Christianity. Quoting statistics from a 1995 survey by the SABC, she stated that ATR is a minority in its birthplace (with only 5% representation), and posed the question: “If ATR is a minority in its place of birth, where is it a majority?” Her presentation put forward the need to study and interpret ATR introspectively, but acknowledged that more “homework” would be needed in this regard.

Dr Mndende thanked the university, Dr Ntombana, and the Dean of the Faculty of Theology, Prof Fanie Snyman, for inviting her, and expressed a desire for the relationship with the UFS to continue.

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