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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

CTL experiments with mobile technology in teaching and learning

2016-05-23

Description: CTL experiments with mobile technology Tags: CTL experiments with mobile technology

On the left is Nokukhanya Nkosi, Researcher and Project manager at the Centre for Teaching and Learning presenting Annah Nggoepe her brand new laptop as part of the project which assesses the impact of personal mobile devices on teaching and learning.
Photo: Supplied

Video clip

Same curriculum. Add technology. Wait and see what happens. This research project which is funded by the Department of Higher Education and Training (DHET) seeks to understand the impact of personal mobile devices (PMD) in teaching and learning.

The University of the Free State (UFS), in conjunction with the University of Cape Town, the University of the Witwatersrand, the University of Johannesburg, and Sol Plaatje University, was approached by the DHET to spearhead this national collaborative project. Investigating whether the financial investment of a PMD on either the part of a university or of students adds value to the teaching and learning experience is the overall objective of the project.

Contemporary education
The Centre for Teaching and Learning (CTL) at the UFS have been taking an active part in the project since 2015, focusing specifically on the use of personal mobile devices in teaching and learning by both staff and students.

At the student level, the study will focus specifically on not just the obstacles that first-generation students face in terms of using technology in teaching and learning, but how institutions can support these students through access to these devices. “In 2015, the CTL conducted the Digital Identity Study of students which highlighted the view that students at the UFS deemed laptops to be the most important PMD in their studies,” said Nokukhanya Nkosi, Researcher and Project manager at the CTL.

In April 2016, thirty students were presented with laptops funded by the project grant. For the next two years, the CTL will assess whether these laptops enable greater flexibility and effectiveness of teaching and learning, both inside and out of the classroom for these students.

Rise of the digital classroom
Annah Ngoepe, a second-year Geography and Environmental Management student taking part in this study, commends the shift from using only textbooks in the past to incorporating technology. “The laptop has the latest applications and programmes, which are convenient for me as a student, because they help in my learning. I can also download textbooks, get summaries of the textbooks, and even other people’s views on a particular subject online.”

Tiana van der Merwe, Deputy Director at the CTL, anticipates that, after two years, the Centre would be able to make not only institutional recommendations, but also recommendations to the National Department of Higher Education.

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