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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Strydom helps establish SA in international clarinet arena

2016-06-07

Description: Danré Strydom Tags: Danré Strydom

Danré Strydom, clarinet lecturer in
the Odeion School of Music at the
University of the Free State, was
named national chairperson to
represent South Africa in the
International Clarinet Association.
Photo: Odeion School of Music.

Her appointment holds international benefits not only for the University of the Free State (UFS), but also for the rest of South Africa’s clarinet community.

This is the view of Danré Strydom, clarinet lecturer in the Odeion School of Music (OSM) at the UFS, on her appointment as South African chairperson of the International Clarinet Association in Columbus (Ohio), America.

It is no coincidence, therefore, that the OSM, with Strydom at the helm as Buffet artist, will present an international clarinet festival on the Bloemfontein Campus from 4 to 8 October 2016. During the International Clarinet Extravaganza, a first for South Africa, world-renowned clarinet players like Eddy Vanoosthuyse of Belgium, Marco Mazinni of Peru, and Sun Zhen of China, will perform.

More contact with overseas representatives
“South Africa’s clarinet community is fairly distanced from the rest of the world,” says Strydom. “In places like Europe and the USA, it is easy to attend a variety of masterclasses, research opportunities, and clarinet festivals.” Her appointment means that she will have more contact with representatives from other countries. “It is also important for composers from South Africa to have their work performed beyond our borders.”

The purpose of the International Clarinet Association is to support projects that benefit clarinet players. She also writes for the association’s journal.

Strydom, who is completing her PhD this year, was honoured some seven months ago with the elite international accomplishment of Buffet artist. She is the first South African to represent Buffet-Crampon.

Clarinet festival offers additional opportunities
Strydom says the clarinet festival hosted by the UFS is “a wonderful opportunity to put the UFS, OSM, and South Africa on the map for clarinet performance, education, and research.”

The purpose of the festival is to expose South African clarinettists and educators to international trends, and to learn from the best in the world. “The festival will prove that the current education, compositional techniques, standard of players, and the quality at academic institutions can compete with the rest of the world. I also believe it will provide opportunities for students to connect with international players and, in that way, open doors for possible postgraduate studies or concert opportunities overseas.”

Watch videos of Strydom:
Video 1
Video 2

Click here to watch other videos of the OSM.

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