Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Afrikaans speakers should think differently, says Coenie de Villiers

2016-06-08

Description: Coenie de Villiers Tags: Coenie de Villiers

Coenie de Villiers was the speaker at the DF Malherbe
Memorial Lecture, held in the Equitas Building on the
University of the Free State Bloemfontein Campus on
24 May 2016.
Photo: Stephen Collett

Do not ask what can be done for your language, but what your language can do for others. With this adaptation of the late John F. Kennedy’s famous words, Coenie de Villiers stressed that the onus for the survival of their language rests with Afrikaans speakers.

According to the television presenter and singer, the real empowerment of Afrikaans does not necessarily take place in parliament. He was the speaker at the DF Malherbe Memorial Lecture, presented in the Equitas Building on the University of the Free State Bloemfontein Campus on 24 May 2016. The lecture by De Villiers, a UFS alumnus, was titled Is Afrikaans plesierig? ’n Aweregse blik.

Government not the only scapegoat
He used Kennedy’s famous phrase, Ask not what your country can do for you, but what you can do for your country, as framework. “I believe that, if we reverse our sights and do not ask what the world can do for Afrikaans, but ask for a change what Afrikaans – and in particular each and every user thereof – can do for others, then we have, in good English terms, ‘a fighting chance’ that Afrikaans will not only survive, but that it will thrive.” He said it would be too easy to just blame the government’s language policy and/or its lack of application for the language’s uncertainties.

Speakers should act correctly
He said the actions of speakers, sometimes motivated by a love for the language, often causes more damage. “It is not the language that should squirm under the microscope. It isn’t Afrikaans that is being tested: it is us, the speakers, writers, thinkers, doers, and tweeters of the language that are being measured.”
De Villiers believes one should stand up for your language without hesitation or fear, but not necessarily in the middle of the road, and never in such a way that you abandon the moral compass of humanity.

Language will live on
He told the audience that Afrikaans speakers should maintain their language every day with the merit, humanity, and respect that they believe the language – and they themselves – deserve. The language will “live on as long as we use it to laugh, and talk, and sing, and do not kill it off with rules and directives.”

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept