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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Race, technology, and maritime labour in the 19th century

2016-06-23

Prof John T. Grider

“When employers
impose
worker identity,
it creates problems.”

What does identity mean to people today, and how is it formed? Religion, politics, race, ethnicity, and gender make up individual and community identity. However, Prof John Grider (University of Wisconsin – La Crosse) is of the opinion that employment moulds our identity, since we spend so much time on the job.

Prof Grider joined the Institute for Reconciliation and Social Justice (IRSJ) on the Bloemfontein and Qwaqwa Campuses to discuss his research on the maritime industry, published in his book, Foreign Voyage - Pacific Maritime Labour Identity: 1840 to 1890. “When employers impose worker identity, it creates problems,” he said. Particularly, this “creates instability in communities, and a vulnerability and insecurity amongst the employees”.

To illustrate his point, Prof Grider expanded on the history of 19th-century Atlantic sailors, a highly-skilled workforce, who failed to adapt to changes in their labour environment. Initially, the sea-faring community was very diverse racially. However, as the Pacific, and particularly Asian, marine community gained precedence, this tide turned to such an extent that, in 1886, the Atlantic sailors formed their own Coastal Seamen’s Union in San Francisco, causing a split between Asian and non-Asian sailors. Atlantic sailors had failed to integrate with the new technology of the day (steam power), nor had they accepted the demographic changes that flooded their community rapidly with cheap labour from Chinese shores.

Prof Grider highlighted the need to maintain an adaptable mentality in the ever- and rapidly-changing labour world, since division amongst workers could lead only to further exploitation of the workforce.

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