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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Trauma, Forgiveness, and Reconciliation Studies attracts global attention

2016-06-27

Description: Lerato Machetela Tags: Lerato Machetela

Lerato Machetela is on her way to
Ghent University in Belgium where
she will spend 10 months working
alongside experts in the field of
historical trauma.
Photo: Eugene Seegers

Research excellence is one of the major driving forces at the core of the University of the Free State (UFS). This striving for academic distinction has found embodiment within Trauma, Forgiveness, and Reconciliation (TFR) Studies. Headed by Research Fellow and Senior Research Professor Pumla Gobodo-Madikizela, the research unit is raking in achievements consistently.

Cornell University Distinguished African Scholar Award
Leading by example, Prof Gobodo-Madikizela received the prestigious 2016 Distinguished African Scholar Award from Cornell University recently. Being honoured with this award affirms an unusual depth of knowledge and experience in a field related to the recipient’s own work. Through this award, Prof Gobodo-Madikizela is now also affiliated with the Institute for African Development and the Psychology Department at Cornell University.

Ghent University fellowship in historical trauma
Another member of TFR has caught international attention. Lerato Machetela – a PhD student at the research unit – received an invitation from scholars at Ghent University in Belgium. Machetela will leave in September, where she will spend ten months in Ghent with experts in the field of historical trauma. She will be affiliated to their university’s Cultural Memory Studies Initiative and the Psychology Department. When Machetela submitted her PhD proposal on transgenerational transmisison of trauma among the youth in Jagersfontein to the UFS Psychology Department panel, “it was hailed as a unique project, and a first for the department,” Prof Gobodo-Madikizela says.

Description: Naleli Morojele Tags: Naleli Morojele

Naleli Morojele conducting the research
in Rwanda that has formed the basis of
her new book, Women Political Leaders
in Rwanda and South Africa: Narratives
of Triumph and Loss.

Book explores triumph and loss of female political leaders
TFR cultivates thriving authors actively, the latest being Naleli Morojele, who is pursuing a PhD in the field of Political Studies. Soon, Morojele will be launching her book, Women Political Leaders in Rwanda and South Africa: Narratives of Triumph and Loss. Through the stories of significant female Rwandan and South African leaders, the reader gains insight into these women’s early-life experiences, struggles, and successes. Perhaps even more pertinently, Morojele’s book also exposes the ways in which gender inequality still works to smother their roles as citizens and politicians.

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