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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS Centenary 2004/05 : October snippets
2004-10-06

CENTENARY CONFERENCE
The proposed Centenary Conference on Democracy, Diversity and Development : Towards a mature and robust society – A critical discourse, refers. Unfortunately many invited contributors are unable to attend on the proposed dates (12 to 15 October 2004) prompting the UFS management to reconsider the timing of the conference. The UFS management has therefore decided to postpone this conference until an appropriate time in 2005.

As a result of this postponement the SAUVCA activities will also no longer be part of the October programme in Bloemfontein.

CENTENARY COMPLEX
The rehabilitation of the existing Reitz Hall and adjoining residence into the Centenary Complex is almost complete.

The inauguration of the complex – Reitz Hall and DF Malherbe House – will take place on Tuesday, the 12th of October 2004. A special open day from 11:00 until 16:00 is planned to enable all staff and students to visit this prestige complex. More detail will be available early October 2004.

FILM PREMIERE
The premiere of an UFS commissioned documentary, as part of its Centenary celebrations, on the remarkable leadership, reconciliatory and nation-building role of King Moshoeshoe, the Basotho leader of the nineteenth century, will take place on Wednesday, the 13th of October 2004. The director of this commissioned documentary is the well-known Max du Preez. Although this event is open to invited guests only, the documentary will also be screened by the SABC later this year. It will also be screened at several other occasions to enable staff and students to experience and discuss this film.

With this film and other projects the University of the Free State wishes to celebrate the legacy of this extraordinary African leader for the Free State and for South Africa.

CENTENARY HONORARY DOCTORATE GRADUATION CEREMONY
A special Honorary Doctorate Graduation Ceremony will take place on the 14th of October 2004 at 19:00 in front of the Main Building on the UFS campus. Twelve honorary doctorate degrees will be awarded to a diverse group of outstanding South Africans and international scholars. The Rector requests the attendance of all staff and students in large numbers during this prestige event.

The following candidates will receive an honorary doctorate degree: Me Antjie Krog, Prof Jakes Gerwel, Mr Karel Schoeman, Dr Frederick van Zyl Slabbert, Prof Saleem Badat, Dr Khotso Mokhele, Prof Robert Bringle, Prof Leo Quayle, Prof Jack de Wet, Prof Kerneels Nel (posthumous), Prof Boelie Wessels en Prof Jaap Steyn .

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