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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Meet our Council: Loraine Roux – a proud Kovsie ambassador

2016-07-01

“I strive to represent the alumni
actively as an interest group,
and to help build the university
through sound business principles.”

Loraine Roux (née Kriek), former President of the Student Representative Council, was elected to the Council of the University of the Free State (UFS) in 2012. This former Kovsie made her mark at the UFS. Many staff members and former students will remember her as the beautiful brainbox, who achieved success in so many different areas of student life and humanity.

Loraine’s studies

Her journey as a Kovsie started as finalist in the prestigious Matriculant of the Year competition. Later, she obtained a Bachelor’s degree in Consumer Science at the UFS. Loraine, a born leader, was also Prime of Soetdoring residence, and remains the only student in the history of the university to be chosen as SRC President, Rag Queen, and Dux student in the same year.

After university

The Kriek family are all stalwart former Kovsies, with three generations – Loraine, her late grandfather Johan Kriek, and godparents, Rhyno and Mariette Kriek – having served on the Student Representative Council. So, it is no surprise that a leading firm like Deloitte & Touche noticed Loraine’s unique talent and leadership skills, and snatched her up for their CEO Bootcamp immediately after university.

Serving on the UFS Council

Currently, she is part of the team that is extending Deloitte & Touche’s ethical and fraud prevention services across Africa and Europe. She also uses her expertise and experience in risk management, ethical practice, and good corporate governance for her role as UFS councillor. As part of her duties as Alumni representative in the Council, she serves on the Naming Committee, as well as on the Audit and Risk Committee.

“It is a great privilege for me to serve on the Council, but it is also a great responsibility,” she says. “I strive to represent the alumni actively as an interest group, and to help build the university through sound business principles.”

Loraine married Gabriel Roux in 2014, and the couple live in Stellenbosch.

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