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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

“Every journey begins with the first steps” – Marguerite van der Merwe

2016-07-08

Description: Marguerite van der Merwe Tags: Marguerite van der Merwe

Marguerite van der Merwe, recipient of University of the
Free State Chancellor’s Medal, with Chancellor
Dr Khotso Mokhele, at the Winter Graduation ceremony.
Photo: Johan Roux

Marguerite van der Merwe has dedicated her life to the enrichment and increased quality of life for others. At the University of the Free State’s Winter Graduations on 30 June 2016, Van der Merwe and her brother, Anthony Douglas Osler, were both honoured with Chancellor’s Medals for exceptional service to South Africa and the world beyond our borders. In the early 1980s, she learned about the Alexander Technique and her life since then has been about perfecting the technique and sharing it with others. The Alexander Technique teaches people of any age, gender, occupation or interest, how to be posture-aware and perfect, how to be aware and alert, and how to be calm and discriminating, all of which are part of a practical teaching to integrate these qualities consciously into all our daily human activities.

She walks the walk

She understood the Alexander Technique to be the perfect way to develop the body both physically and mentally, as it develops the higher mental faculties like focus, attention, awareness, consciousness, discrimination, and unfolding of the psyche, thus developing the human potential holistically as a spiritual way of being. She received her training for the technique in Cape Town and London, thereafter she published The Art of Walking, a guide to the Alexander Technique.

Van der Merwe is an internationally-certified teacher of the Alexander Technique, has been offering this work and its application in the spheres of health, education, and performance skills for 30 years, both nationally and internationally.

Van der Merwe says that the South African higher education system should encompass a holistic approach to teaching and educating. Education should envisage a modern vision of education that supports the evolution of the potential of the human being as a holistic system – a competent, skilled, caring, kind individual, developed in physical, mental, emotional and sensorial aspects. She believes that students thus educated will model ‘wholeness’ and ‘humanness’ as they take their place in society, business, education, and entrepreneurship.

Enriching women’s potential

Apart from The Art of Walking, Van der Merwe published EVE-OLUTION, a book to inspire women to listen to their intuition, and empower women to repossess their bodily wisdom, freedom, and authenticity. Van der Merwe proclaims that it is important to liberate women to take charge of their own bodies, minds, and souls. The purpose of the book is to ensure that young women soak up wisdom and encouragement and for older women to express their wisdom, which needs to be respected and listened to.

“Females and feminine roles in society and family are being liberated and acknowledged in the actions of many women as we stand for equal opportunity, equal power, and equality in many fields,” says Van der Merwe.
“Our young women in business and the higher education fraternity, for one, are strong in their views, beautiful in their presence, outspoken in leadership,” Van der Merwe concluded.

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