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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Monkey research attracts international attention

2016-07-11

Prof Trudy Turner from the University of
Wisconsin-Milwaukee and Prof Paul Grobler
from the Department of Genetics at the
University of the Free State, together with one
of the students researching monkey genes.
Photo: Siobhan Canavan

For this year’s Summer School programme, Prof Paul Grobler, from the University of the Free State Department of Genetics focuses on research about the conflict between monkeys and humans in areas where monkeys are regarded as problem animals.

Global expert part of research

This year, Prof Grobler is hosting a group of students and lecturers from the United States of America (USA). The group includes Prof Trudy Turner from the University of Wisconsin-Milwaukee (UWM), a global expert on vervet monkeys. She has been working with the Department of Genetics at the UFS for the past fifteen years, and has also been appointed as an Affiliated Professor in the department.

“The Summer School programme is an opportunity for the American Primatology students to gain practical experience in Africa,” says Prof Grobler.

International interest in Summer School

This year’s Summer School programme involves four lecturers and nine students. The lecturers are from the University of Wisconsin-Milwaukee (UWM), the University of California, Los Angeles (UCLA), Boston University, and Central Washington University.

“We use the genetic information to determine
how monkeys historically infiltrated the
different areas in South Africa.”

This year’s focus is on the genetic structure of the monkeys in South Africa, and research that is being done on the differences and similarities in monkeys from different areas. “We use the genetic information to determine how monkeys historically infiltrated the different areas in South Africa,” says Prof Grobler.

Local nature reserve acting as host

The group will perform field work, including observing monkeys in the Soetdoring Nature Reserve, as well as laboratory work in the department, where they will be assisted by two laboratory technicians.

Two years ago, Prof Grobler and his department tested this idea on a smaller scale, and now they hope to make this a regular event.

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