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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Plant eco-physiologist finds effective solutions for crop optimisation

2016-07-24

The bio-stimulant was tested on
this citrus. This is the first time
that the product has been tested
on a crop.

In a time characterised by society facing increasing population growth, food crises, and extreme climatic conditions such as drought, it is essential for farmers to integrate science with their work practices in order to optimise crops.

Role of photosynthesis and plant sap data

By knowing how to use photosynthesis and plant sap data for determining plant health, fast and effective solutions could be established for the optimisation of crops. This technique, which could help farmers utilise every bit of usable land effectively, is the focus of Marguerite Westcott’s PhD study. She is a junior lecturer and plant eco-physiologist in die Department of Plant Sciences at the University of the Free State.

Westcott uses this technique in her studies to prove that a newly-developed bio-stimulant stimulates plants in order to metabolise water and other nutrients better, yielding increased crops as a result.

Agricultural and mining sectors benefit from research

The greatest part of these projects focuses on the agricultural sector. Westcott and a colleague, Dr Gert Marais, are researching the physiology of pecan and citrus trees in order to optimise the growth of these crops, thus minimising disease through biological methods. Field trials are being conducted in actively-producing orchards in the Hartswater and Patensie areas in conjunction with the South African Pecan Nut Producers Association (SAPPA) amongst others.

The principles that Westcott applies in her research are also used in combination with the bio-stimulant in other studies on disturbed soil, such as mine-dump material, for establishing plants in areas where they would not grow normally. This is an economical way for both the agricultural and mining sectors to improve nutrient absorption, stimulate growth, and contribute to the sustainable utilisation of the soil.

The bio-stimulant contributes to the immunity of the plants.
It was tested in these pecan nut orchards (Hartswater).

Soil rehabilitation key aspect in research projects

“One of two things is happening in my research projects. Either the soil is rehabilitated to bring about the optimal growth of a plant, or the plants are used to rehabilitate the soil,” says Westcott.

Data surveys for her PhD studies began in 2015. “This will be a long-term project in which seasonal data will be collected continuously. The first set of complete field data, together with pot trial data, will be completed after the current crop harvest,” says Westcott.

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