Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

RSG Crossword Tournament helps to celebrate language

2016-07-27

Description: RSG Crossword Tournament Tags: RSG Crossword Tournament

Dr Annette de Wet (left), Assistant Director
of the Unit for Language Development in
the Centre for Teaching and Learning at
the UFS, Albe Grobbelaar from XWord,
Prof Angelique van Niekerk, Head of the
Department of Afrikaans and Dutch, German
and French, and Prof Lucius Botes, Dean of the
Faculty of the Humanities, during the launch
of the RSG Crossword Tournament.
Photo: Jóhann Thormählen

Sometimes it is difficult for language departments to be topical and to show their relevance for the people out there. However, with the RSG Crossword Tournament, this became possible and Afrikaans could be celebrated in a positive manner. This is what Prof Angelique van Niekerk, Head of the Department of Afrikaans and Dutch, German and French at the University of the Free State (UFS), had to say about this initiative.

Interest during the Vrystaat Arts Festival exceeded all expectations. Altogether, 46 participants from across the country participated on 15 and 16 July 2016. Ilse van Hemert from Pretoria was crowned as the first South African crossword champion.

New dimension to language milieu

Prof Van Niekerk said people are familiar with crossword puzzles from the media, and it was the first time that a tournament like this was presented to the public in South Africa. “This tournament brings something like linguistics and linguistic sensitivity to the fore,” she said. “It is another dimension of the language milieu.” This is exactly why her department would like to see it grow in future.

Wordplay serves as inspiration

The idea for the tournament is based loosely on the film, Wordplay (2006), which is set in New York, and the annual New York Times Crossword Tournament. The South African Tournament was presented in conjunction with the crossword group, XWord, Prof Van Niekerk’s department, and the radio station RSG as brand sponsor.

Crossword puzzles and blockbusters crosswords completed

“This tournament brings something like
linguistics and linguistic sensitivity to
the fore.”

Albe Grobbelaar from XWord said the winners were determined on a points basis. “Competitors had to complete two crossword puzzles and one blockbuster crossword. The difference between the two is that a blockbuster’s clues are within the blocks or grid, but with the crossword, you have white and black blocks with the clues separate on the outside.”

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept