Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Beauty personified through written word

2016-07-29

Description: Zubeida Jaffer Tags: Zubeida Jaffer

Dr Thozama April, University of Fort Hare
historian, Zubeida Jaffer, current Writer-in-Residence
in the Department of Communication Sciences
at the UFS and author of Beauty of the Heart:
The life and times of Charlotte Mannya Maxeke
and Prof Jonathan Jansen, Vice-Chancellor and Rector
of the UFS at the book launch of Zubeida Jaffer.
Photo: Rulanzen Martin

“It is quite easy to write a book in a professional capacity but very difficult to write a book from the heart.”

These were the words of Prof Jonathan Jansen, Vice-Chancellor and Rector of the University of the Free State (UFS), at the launch of Beauty of the Heart: The life and times of Charlotte Mannya Maxeke by Zubeida Jaffer, the current Writer-in-Residence in the Department of Communication Sciences at the UFS.

Perseverance and dedication yields results

Writing a book from the heart is exactly what Jaffer, an award-winning South African journalist and author, set out to do. “When you make the choice to write a story, you need to be very dedicated,” she said.

As this is Jaffer’s third book, one would think that she would have no difficulty in putting pen to paper. On the contrary, she mentioned that it was, in fact, the hardest book she has written because the narrative was not easy to get hold of.

“I wanted Charlotte’s voice to come through, and it took my team and I three years of research and writing,” she said.

Maxeke’s story helps to shape South African society

The three-person panel, hosted by the UFS Sasol Library and SUN MeDIA, and chaired by Prof Jansen, included Jaffer and Dr Thozama April, University of Fort Hare historian who had done her PHD thesis on Maxeke.

Dr April said that Maxeke’s life story is an inspiring one, as it encourages a rethinking of established narratives. “These established narratives have made it possible for historians and researchers to write about the shaping of South African society,” she said.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept