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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

The Shepherd Centre celebrates decade of empowering spiritual leaders

2016-08-01

The Shepherd Centre functions under the auspices of the Faculty of Theology at the University of the Free State (UFS), and arose out of a need for non-denominational adult-learning programmes for those actively involved in the ministry. According to the director, Dr Gerhard Botha, the centre came into being to assist spiritual leaders: “The Shepherd Centre takes on the shepherding responsibility for spiritual leaders of all Christian churches.”

Planning started in 2005, when the need was identified for foundation-phase education in the wider church community. Dr Botha was appointed as the director of the centre in 2006, and given the task of compiling a suitable curriculum. The aim of the curriculum is to enable spiritual leaders to provide current interpretations of scripture for a modern society. From the first handful of students a decade ago, The Shepherd Centre has grown by mid-2016 to 300 adult learners enrolled in the short learning programmes, many of which are catered for at the satellite sites in Kimberley, Koffiefontein, Kroonstad, Qwaqwa/Kestell, Thaba Nchu, Zeerust, and the South Campus of the UFS.

This initiative has extended its reach even further than the boundaries of the Free State. In 2014, Dr Botha and Prof Fanie Snyman, Dean of the Faculty of Theology, visited Ethiopia, and signed an agreement of mutual collaboration with the Full Gospel Church there. In addition, a Shepherds4Africa programme is involved in Christian communities and with Christian religious leaders in several other countries, providing training opportunities to various indigenous churches, with the greater vision of spreading the Word to all countries in Africa and beyond. Dr Botha states that their hope is to provide the tools needed in order to make the community of faith as healthy so as to build its moral fibre.

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