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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Students applaud Prof Jansen one last time
2016-08-11

Description: The Talk To Me  Tags: The Talk To Me

Prof Jonathan Jansen, Vice-Chancellor and Rector of the
University of the Free State, talks to a student outside the
Library of the South Campus on Tuesday 26 July 2016
during the Talk To Me session.
Photo: Rulanzen Martin

“The Talk To Me session made me feel like I mattered.”

This was one of the compliments the University of the Free State (UFS) and Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS, received after the last Talk To Me sessions for the year.

On 25 and 26 July 2016, Prof Jansen gave staff and students on the Bloemfontein and South Campuses a chance to pull up a chair and have a chat with him on issues that mattered to them.

The students commended Prof Jansen on this great initiative as they felt their voices were being heard. It allowed them an opportunity to speak to him directly, as well as to make suggestions on things they were concerned about. “I really appreciate this manner of allowing students to have a chat with Prof Jansen,” a student said, giving feedback on the session.

Students were very pleased with the professionalism and organisation of the whole session, but requested that it be held more often, therefore giving more students the opportunity to converse with Prof Jansen. The majority of the students suggested that the session with Prof Jansen should run longer than just an hour as there were a large number of students who would appreciate a heart-to-heart chat with Prof Jansen.

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