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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Research on locomotion of giraffes valuable for conservation of this species

2016-08-23

Description: Giraffe research 2016 Tags: Giraffe research 2016

Technology was used in filming the giraffes.
According to research, giraffes will slow
down when a drone is positioned
approximately 20 - 30 m away. When the
drone moves closer, they will revert
to galloping.
Photo: Charl Devenish

The meaning of the Arab term Giraffe Camelopardalis is ‘someone who walks fast’. It is precisely this locomotion of their longnecks that encouraged researchers, Dr Francois Deacon and Dr Chris Basu, to study the animals more closely.

Despite the fact that giraffes are such well-known animals, very little research has been done on the manner in which these graceful animals locomote from one place to the next. There are only two known ways of locomotion: the slower lateral walking and the faster galloping. Most animals use these ways of moving forward. It is unknown why giraffes avoid intermediate-speed trotting.

Research of great value to the industry
Research on the manner in which giraffes locomote from one place to the next will assist the industry in understanding aspects such as their anatomy and function, as well as the energy they utilise in locomoting from one place to another. Information on the latter could help researchers understand where giraffes fit into the ecosystem. This data is of great value for large-scale conservation efforts.

Universities working together to collect data
Dr Basu, a veterinarian at the Royal Veterinary College in the UK, has studied the animals at a zoo park in the United Kingdom. He visited the University of the Free State (UFS) in order to expand his fieldwork on the locomotion of giraffes. This study was done in cooperation with Dr Deacon from the Department of Animal, Wildlife, and Grassland Sciences at the UFS. Dr Deacon is a specialist in giraffe habitat-related research in South Africa and other African countries.

The fieldwork for the research, which was done in the Woodland Hills Wildlife Estate and the Willem Pretorius Nature Reserve, preceded research on the movement and the forces involved in the locomotion of giraffes. Due to the confined fenced area in the zoo park, it was practically impossible to study the animals at speed. “The study of actions ‘faster than walking’ is crucial for gathering data on, inter alia, the frequency, length, and time associated with each step.

Technology such as drones offers unique
opportunities to study animals like giraffes.

Technology used to ensure accuracyTechnology such as drones offers unique opportunities to study animals like giraffes. Apart from the fact that it is possible to get high-quality video material of giraffes – moving at speed – it is also a very controlled device that ensures the accuracy of data.

It is the first time ever that a study has been done on the locomotion of giraffes with this level of detail.
Research on the study will be published in the Journal of Experimental Biology.

The project was approved by the UFS ethics committee.

Previous research articles:

9 March 2016:Giraffe research broadcast on National Geographic channel
18 Sept 2015 Researchers reach out across continents in giraffe research
29 May 2015: Researchers international leaders in satellite tracking in the wildlife environment

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