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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Incidents on the Bloemfontein Campus

2016-08-25

Statement by the Institutional Forum of the University of the Free State (UFS) - Released by Dr Willy Nel (Chairperson) on behalf of the Institutional Forum of the UFS

Two incidents happened on campus the past week, which were brought to the attention of the university management:

1. The university management received a complaint on 16 August 2016 that a student had sprayed liquid in the face of a security guard at one of the university gates. The reason appears to be that three students were sent back to their residence to collect their student cards in order to exit the campus – as required – and this might have caused the reaction. In video footage, it is clear that a student on the passenger side was responsible for the spraying incident. Statements have been taken from the three students in the car as well as from the affected security guard. The student claims that the liquid was water from his gym bottle. Regardless, charge sheets were prepared and delivered, and the disciplinary hearing has been scheduled on an urgent basis for 1 September 2016.

2. An incident happened on the Bloemfontein Campus on 23 August 2016, with a test being distributed in a class where the answer to one of the questions was included in the Afrikaans version, while it was excluded in the English version. The matter was investigated and it was decided that the written test will be set aside and a new test, covering the same scope, will be compiled for all students; the new test will be subject to external moderation; and external moderation of tests in the particular department will take place until the end of the year. The lecturer concerned claims that this was a genuine mistake and not intentional, in that guidelines for that one question were removed after a decision to add further examination questions, which made the guidelines obsolete; in the process of revising the papers, the lecturer made a mistake and did not remove the guidelines for both the English and Afrikaans versions. Nonetheless, the university management has decided on a disciplinary process involving the lecturer concerned, given the seriousness of the matter.

Released by: Lacea Loader (Director: Communication and Brand Management)
Tel: +27 51 401 3422/2707 or +27 83 645 2454
Email: news@ufs.ac.za | loaderl@ufs.ac.za
Fax: +27 51 444 6393

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