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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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‘Captivating, powerful’ exhibition debuts at UFS
2016-08-29

Description: Sue Williamson exibition Tags: Sue Williamson exibition

Sue Williamson, What is this thing called freedom?, 2016 (two-channel video, 19min 25s)

A new exhibition by internationally-recognised artist, Sue Williamson, entitled No More Fairytales, was launched in the Johannes Stegmann Gallery on the Bloemfontein Campus of the University of the Free State (UFS) on 18 August 2016. The exhibition takes the audience on an exploration into the long-term effects of South Africa’s violent past.

No More Fairytales features two new video works. In It’s a pleasure to meet you, Candice Mama and Siyah Mgoduka—whose fathers were killed by Eugene de Kock—talk about living with loss, holding, on, and letting go. The other video, What is this thing called freedom?, draws the audience into a conversation between three generations of women in the Siwani family, who talk about the humiliations of apartheid, student unrest in the 1980s, and the recent #FeesMustFall protests.

“It’s all about opening up conversations.”

Both of these works have already been invited to participate in international exhibitions, the first of which, Un Autre Continent, opens in Le Havre, France, in September 2016. The videos will appear in 2017 in Without Drums and Trumpets—100 Years of War, also in France. The exhibition will run until 16 September 2016 at the UFS.

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Sue Williamson, It's a pleasure to meet you, 2016 (two-channel video, 25min)

“There is such an energy to this large piece of work; there is something captivating, something powerful about its vibrancy,” said Prof Pumla Gobodo-Madikizela, Senior Research Professor in Trauma, Forgiveness and Reconciliation Studies at the UFS. The series was commissioned by Prof Gobodo-Madikizela as part of the project, ‘Trauma, Memory and Representations of the Past: Transforming Scholarship in the Humanities and the Arts’. The five-year research project is funded by the Andrew W. Mellon Foundation through a grant of R10 million.

The launch of the exhibition was followed the next morning by an insightful dialogue session between Prof Gobodo-Madikizela, Mama, Mgoduka, Williamson, and the audience. “It’s all about opening up conversations and trying to bring out things that have been so painful and so hurtful in this country,” Williamson said.

 

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