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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

From a dream to a reality: Free State Mother and Child Academic Hospital
2016-08-31

Description: Free State Mother and Child Academic Hospital  Tags: Free State Mother and Child Academic Hospital

The message, From a dream to a reality, echoed
throughout the launch of the Mother and
Child Academic Hospital. From left to right:
Dr Khotso Mokhele, Chancellor of the UFS,
Rolene Strauss, Miss World 2014 and
Patron of the Mother and Child Academic Hospital,
Prof André Venter, Head of the Department of
Paediatrics and Child Health, and Dr Riaan Els,
CEO of the Fuchs Foundation South Africa.
Photo: Charl Devenish

“Sometimes dreams do come true, and finally, this institution is starting to dream big dreams.” These were the words of Dr Khotso Mokhele, Chancellor of the University of the Free State (UFS) at the launch of the Free State Mother and Child Academic Hospital collaborative initiative. The launch was an official declaration of intentions regarding the establishing of the hospital, a specialist unit which will focus on paediatric and maternal healthcare, fully supported by the Department of Health in the Free State. As the first Mother and Child Hospital in South Africa, it will be unique.

Under the leadership of Prof André Venter, the UFS Department of Paediatrics and Child Health serves over 250 000 children of the southern regions of the Free State at secondary care level, and is responsible for the tertiary care of nearly one million children from the whole of the Free State and Northern Cape Provinces, as well as some children from Northwest and Eastern Cape Provinces and Lesotho.

As part of a multi-faceted initiative, the 350-bed mother and child hospital will benefit the community of the Free State greatly, and will support the objectives of the Strategic Development Goals. It will further Free State Strategic Transformation Plan (STP) by improving access to healthcare for the most vulnerable members of the population, thus reducing paediatric mortality and improving maternal health. An additional objective of the project is to develop academic excellence, and improve the environment in which medical specialists and subspecialists develop their skills according to international standards.

Prof Jonathan Jansen, Vice-chancellor and Rector of the UFS, described the project as one which captures the head and the heart, as it caters most for little lives, a hub wherein great talent and potential waits to be unleashed. In support of the project, the university has offered a piece of land on the campus where the hospital will be built, thus strengthening the quality of tertiary education.

Former Miss World, Mrs Rolene Strauss, also pledged her support. She said she is honoured to be the patron of the project, one she believes will lead to healthier women, healthier children, and a healthier nation.

In celebration of the 50th anniversary of the Fuchs Foundation, CEO Dr Riaan Els, awarded a donation of R2250000 towards the building of the hospital, a contribution which will bring the project a step closer to its realisation.

Prof André Venter, leader of the project, hopes that it will serve as a blueprint for other academic hospitals in the country, and mark the beginning of an era of highly specialised medical care for humanity’s most precious people.

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