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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

First residence for UFS South Campus

2016-09-01

The residence has 146 double rooms with 17 kitchens
overall, each corridor has one kitchen. The residence
also has a gazellie and a conference room that
can accommodate 50 people.
Photo: Charl Devenish

The South Campus of the University of the Free State in Bloemfontein now has its own student residence. Completed in June 2016, the new residence can accommodate 250 undergraduate and 20 postgraduate students.

The residence has 270 beds, with 20 single-bedroom flats and 12 additional single rooms in the corridors. Each of these single-bedroom flats has a kitchen, lounge, and a bathroom. There are 146 double rooms with 17 kitchens overall, each corridor has one kitchen. The residence also has a gazellie, a conference room that can accommodate 50 people, as well as eight laundry rooms with a drying area.

“Students at the South Campus have, up until now, been commuting from the Bloemfontein Campus and residential areas around town. We are extremely proud that accommodation will now be available to our students on the campus. Although the official opening of the residence is said to take place early in 2017, some students have already moved in,” says Prof Daniella Coetzee, Principal of the South Campus.

The residence was built at a cost of R57 million, which was funded by the UFS and the Department of Higher Education and Training.

Residence accessible to differently-abled people
The UFS strives to cater for differently-abled people by making all its buildings accessible to them. This residence is no exception, as it has two rooms available on the ground floor of Block C for differently-abled students. These rooms accommodate two students per room.

A one-of-a-kind newly installed water system
The residence is also the first at the university that has a grey-water system installed. Grey water is made up of bath, shower, and bathroom sink water. The water will then be reused for toilet flushing as well as for irrigation purposes on the campus.

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