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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Students receive hands-on crime scene investigation training
2016-09-02

Description: Crime scene investigation training Tags: Crime scene investigation training

Ntau Mafisa, a forensic science honours student
at the UFS, and Captain Samuel Sethunya from
the SAPS Crime Scene Management in
Bloemfontein.
Photo: Leonie Bolleurs

With murder and robbery rates on the rise, the Forensic Science Programme of the Department of Genetics at the University of the Free State is playing a key role in training South Africa’s future crime scene investigators and forensic laboratory analysts.

According to the Institute for Security Studies (ISS), murder and aggravated robbery rates for 2014/2015, as recorded by the South African Police Services (SAPS) have increased. Incidents of murder increased by 4.6% in the period from 2013/2014 to 2014/2015 and aggravated robbery increased by 8.5 % in the same period. The ISS is an African organisation thant enhances human security by providing independent and authoritative research, expert policy advice and capacity building.

Dr Ellen Mwenesongole, a forensic science lecturer at the Department of Genetics, said the university was one of a few universities in South Africa that actually had a forensic science programme, especially starting from undergraduate level.

Crime scene evaluation component incorporated in curriculum
As part of its Forensic Science Honours Programme, the department has, for the first time, incorporated a mock crime scene evaluation component in its curriculum. Students process a mock crime scene and are assessed based on how closely they follow standard operating procedures related to crime scenes and subsequent laboratory analysis of items of possible evidential value.

The mock crime scene forms part of a research project data collection of the honours students. In these projects students utilise different analytical methods to analyse and distinguish between different types of evidence such as hair fibres, cigarette butts, illicit drugs and dyes extracted from questioned documents and lipsticks.

Students utilise different analytical methods to analyse
and distinguish between different types of evidence.

This year, the department trained the first group of nine students in the Forensic Science Honours Programme. Dr Mwenesongole, who received her training in the UK at the University of Strathclyde in Glasgow, Scotland, and Anglia Ruskin University in Cambridge, England, said incorporating a crime scene evaluation component into the curriculum was a global trend at universities that were offering forensic science programmes.

Department of Genetics and SAPS collaborate
It is important to add this component to the student’s curriculum. In this way the university is equipping students not only with theoretical knowledge but practical knowledge on the importance of following proper protocol when collecting evidence at crime scenes and analysing it in the laboratory to reduce the risk of it becoming inadmissible in a court of law.

The Genetics Department has a good working relationship with the Forensic Science Laboratory and Free State Crime Scene Management of the Division Forensic Services of the SAPS. The mock crime scene was set up and assessed in collaboration with the Crime Scene Management Division of the SAPS. Although the SAPS provides specialist advanced training to its staff members, the university hopes to improve employability for students through such programmes.

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