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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS lecturer overcomes barriers to become world-class researcher

2016-09-05

Description: Dr Magteld Smith researcher and deaf awareness activist Tags: Dr Magteld Smith researcher and deaf awareness activist

Dr Magteld Smith researcher and deaf awareness
activist, from the Department of Otorhinolaryngology
at the UFS.
Photo: Nonsindiso Qwabe

Renowned author and disability activist Helen Keller once said the problems that come with being deaf are deeper and more far-reaching than any other physical disability, as it means the loss of the human body’s most vital organ, sound.

Dr Magteld Smith, researcher at the Department of Otorhinolaryngology (Ear, Nose and Throat) at the University of the Free State, said hearing loss of any degree can have psychological and sociological implications which may impair the day-to-day functioning of an individual, as well as preventing the person from reaching full potential. That is why Smith is making it her mission to bring about change in the stigmatisation surrounding deafness.

Beating the odds
Smith was born with bilateral (both ears) severe hearing loss, which escalated to profound deafness. But she has never allowed it to hinder her quality of life. She matriculated from a school for the deaf in 1985. In 2008 she received a cochlear implant a device that replaces the functioning of the damaged inner ear by providing a sense of sound to the deaf person which she believes transformed her life. Today, she is the first deaf South African to possess two masters degrees and a PhD.

She is able to communicate using spoken language in combination with her cochlear implant, lip-reading and facial expressions. She is also the first and only deaf person in the world to have beaten the odds to become an expert researcher in various fields of deafness and hearing loss, working in an Otorhinolaryngology department.

Advocating for a greater quality of life
An advocate for persons with deafness, Smith conducted research together with other experts around the world which illustrated that cochlear implantation and deaf education were cost-effective in Sub-Saharan Africa. The cost-effectiveness of paediatric cochlear implantation has been well-established in developed countries; but is unknown in low resource settings.

However, with severe-to-profound hearing loss five times higher in low and middle-income countries, the research emphasises the need for the development of cost-effective management strategies in these settings.

This research is one of a kind in that it states the quality of life and academic achievements people born with deafness have when they use spoken language and sign language as a mode of communication is far greater than those who only use sign language without any lip-reading.

Deafness is not the end
What drives Smith is the knowledge that deaf culture is broad and wide. People with disabilities have their own talents and skills. All they need is the support to steer them in the right direction. She believes that with the technological advancements that have been made in the world, deaf people also have what it takes to be self-sufficient world-changers and make a lasting contribution to humanity.

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