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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Heritage translates into fashion
2016-09-13

Description: Centre for Africa Studies Tags: Centre for Africa Studies

Vuyo Mbutho, winner of the best dressed
traditional wear, and Palesa Mokubung,
acclaimed fashion designer.
Photo: Siobhan Canavan

There is no such thing as overnight success. You need to earn your way to the top through hard work, which is exactly what critically acclaimed fashion designer Palesa Mokubung did.

During the 2016 Heritage Day lecture hosted by the Centre for Africa Studies, entrepreneur, award winner and fashion visionary Mokubung told how she had begun her career with the label Stoned Cherrie. Kroonstad-born Mokubung then formed her own label in 2004 called Mantsho, which is Sesotho for “brutally black”.

A true Mantsho garment can be identified by three elements that describe Mokubung’s knowledge of her craft, namely its confident and effortless silhouette, structure and quirkiness. “I was taught to express myself from a very young age and my job is to give people life through my clothes,” she says.

Under the management and creative leadership of Mokubung, Mantsho has gone on to travel to places such as Greece, India, New York, Jamaica, Nigeria, Botswana, and Senegal showcasing its designs.

Mokubung says she does not look far for inspiration because she lives in such exciting times. “Sometimes the fabrics talk to you and you should listen to them.”

This confident, straight talker with her high standards says that all aspiring fashion designers need to earn their way to the top. “You get over it by getting over it, and by working through it.”

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