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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Interpreting implemented at UFS residences
2007-10-12

The University of the Free State (UFS) has begun to implement interpreting services at student residence meetings on the Main Campus in Bloemfontein, as part of the management of diversity and the racial integration of its residences.

As a pilot project, the interpreting services are being offered since the third term at Emily Hobhouse and Roosmaryn ladies residences, where a significant racial diversity already is present. From next year this service will be extended to all the student residences on the Main Campus.

The interpreting project is being managed by the Department of Afro-asiatic Studies, Sign Language and Language Practice at the UFS.

“Students in training at the Department of Afro-asiatic Studies, Sign Language and Language Practice and senior interpreters from the UFS are currently interpreting during residence meetings,” said Prof. Jackie Naudé, Departmental Chairperson of the UFS’s Department of Afro-asiatic Studies, Sign Language and Language Practice.

“Students in these residences are given the opportunity to be trained to interpret during their residence meetings. Four students from each hostel are being trained as interpreters,” said Prof. Naudé.

According to Prof. Naudé both residences have meetings that take place on a Monday evening at 22:00. Interpreting is also provided at the first-year students’ meetings at Emily Hobhouse on Tuesday evenings.

The interpreters experience the interpreting at the residences as positively and they experience that students often do utilise this service. At Roosmaryn 16-18 students are utilising the interpreting service, while at Emily Hobhouse approximately 18 students are utilising the service.

“The interpreting service definitely contributes to the enhancement of communication during residence meetings. Students can exactly follow what is happening during the meetings. In the past a residences like Emily Hobhouse tried to repeat everything in English, which extended the meetings,” Prof. Naudé said.

With the envisaged extension of interpreting services in hostel meetings to all the hostels on the Main Campus in Bloemfontein, there is a need for interpreters as these meetings will take place simultaneously. Through this initiative, exiting new opportunities are created for aspiring interpreters. The training takes place under leadership of Prof. Annelie Lotriet who holds the ATKV Chair in Interpreting in the department.

Aspiring candidates can contact Mr Cobus Snyman, Manager of the UFS’s interpreting projects at 051 401 9005 in connection with the selection criteria for interpreters.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
14 October 2007
 

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