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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Tswelopele hosts first LGBTQI panel discussion
2016-10-05

Description: LGBTQI  Tags: LGBTQI

Tshepang Mahlatsi, Zane Thela, Dionne van
Reenen, Dr Thierry Luescher and Galeletsang
Soato, at the Brotherhood with no Limit panel
discussion held at Tswelopele residence on
the Bloemfontein Campus.
Photo: Supplied

Ignorance about issues relating to the Lesbian, Gay, Bisexual, Transgender, Queer and Intersex (LGBTQI) community is a threat to mankind. This is according to Tshepang Mahlatsi, former Prime of Tswelopele residence, regarding LGBTQI concerns at University of the Free State (UFS).

House Tswelopele on the Bloemfontein Campus hosted a panel discussion, Brotherhood with no Limit, on 19 September 2016 to discuss issues affecting the LGBTQI community, which has often been on the receiving end of criticism, hate speech and bigotry.

Academics take stance at LGBTQI discussion

The panel, which consisted of staff members and students, opened the discussion to everyone on campus. The panel comprised Zane Thela, Programme Coordinator: Gender and Sexual Equity Office: Student Affairs; Dionne van Reenen, Assistant Researcher; Dr Thierry Luescher, Assistant Director, Directorate for Institutional Research and Academic Planning, and Mahlatsi.

Creating a safer environment for LQBTQI dialogue

“The message that we were putting across was simple. We as a house cannot allow society to define our own brothers for us,” Mahlatsi said. The responsibility of students and student leaders was to stand in solidarity. He said it was not fair that in the 21st century people were still fighting to be recognised for who they were and what they identified themselves as. This issue had been discussed at Tswelopele before and it was not that much of an issue, Mahlatsi said. “However, this was the first formal one [discussion] where we had speakers who are more informed on the topic.”

The panel discussion also aimed to challenge other residences that still do not allow such talks to take place in a safe environment.

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