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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Researcher in mathematics ranks among world’s top peer reviewers
2016-10-07

Description: Abdon Peer Review Tags: Abdon Peer Review

Prof Abdon Atangana, from the UFS Institute
for Groundwater Studies.
Photo: Johan Roux

Thirty-year-old Prof Abdon Atangana has received the prestigious Sentinels of Science Award 2016. This award honours the highest achievers in peer review across the world’s journals. The elite contributors to scholarly peer review and editorial pursuits internationally are also honoured with this award. Recipients have demonstrated an outstanding, expert commitment to protecting the integrity and accuracy of published research in their field.

Prof Atangana, who ranks number one in the mathematics discipline with a merit of 324, is a professor at the Institute for Groundwater Studies at the University of the Free State (UFS).

He is editor of 17 international journals, editor-in-chief of two international journals and also reviewer of more than 200 international accredited journals. He has been lead and guest editor of some special issues. He is also editor of 19 journals of applied mathematics and mathematics and has presented and participated in more than 20 international conferences.

Prof Atangana’s research interests are methods and applications of partial and ordinary differential equations, fractional differential equations, perturbations methods, asymptotic methods, iterative methods, and groundwater modelling.

“Editors in more than 100 journals
trust my opinion to assess
whether a submitted paper
can be published or not.”

Peer review requires a respected expert in a given field

According to the professor, reviewers play a central role in scholarly publishing. “In the academic field, peer review is the process of subjecting an author’s scholarly work, research, or ideas to the scrutiny of others who are experts in the same field, before a paper describing this work is published in a journal or as a book. The peer review process helps the publisher to decide whether the work should be accepted, considered acceptable with revisions, or rejected.

“Peer review requires a respected expert in a given field, who is qualified and able to perform the review in a given timeframe. Due to the impact of my research papers in the field of mathematics and applied mathematics, and also my international recognition in the field of applied mathematics, many editors in more than 100 journals of applied mathematics trust my opinion to assess whether a submitted paper in a given journal of mathematics and applied mathematics can be published or not. Only this year I was able to review more than 100 papers from different journals of applied mathematics, applied physics, mathematics, engineering and hydrology,” he said.

A successful peer reviewer displays passion for the development of science

Key to his success as peer reviewer is his passion for the development of science, his ability to write fair reports about a given manuscript, as well as his knowledge on what has been done and what are the challenges in a given field to be able to give a report that will help the advancement of science.

Currently he is developing new mathematics tools that will be used to accurately model statistical problems as well as physical problems with many layers.

“To be the number one peer reviewer in the world in mathematics is a product of love, patience and determination to enhance science,” Prof Atangana said.

His advice to young researchers is to put their trust in God and to work hard. “Not necessarily for money but for love because the future of Africa is in the hands of young Africans,” he said.

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