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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

State of our campuses: UFS extends vacation as from 28 September until 7 October 2016
2016-09-28

In solidarity with the call for free education for the poor and missing middle, a discussion was held with the University Management Committee this morning, in consultation with the student leadership, and after careful assessment of operational matters on all three campuses of the University of the Free State (UFS), we agreed upon the following:
 
1.    All classes, tests, and assignments will be suspended until Friday 7 October 2016. This means that the university will close on Wednesday 28 September 2016 for an extended vacation until 7 October 2016. The academic programme will resume on Monday 10 October 2016.
                     
2.    This will allow the entire university time to demonstrate solidarity, in collaboration with student leadership, academic and support staff, and the broader community in support of free higher education for the poor and missing middle.
                  
3.    The administration of the university will continue on Thursday 29
September 2016, and staff will have access to their offices to plan the additional academic support for students, to consider the re-scheduling of the academic calendar, to engage with the Department of Higher Education and Training in relation to the students’ demands, and to continue with support services during the extended vacation.
 
4.    The university management and student leadership will also, over the next three days, engage in discussions to provide for a platform that is conducive to continued collaboration between students and the university leadership.
 
5.    The suspension of tests, classes, and assignments will also allow time for a social compact and code of ethics for protests to be agreed upon and signed between student leadership and the university management.

 In respect of the Qwaqwa Campus, some protesting students yesterday intimidated others and forcibly removed staff, as well as security personnel. Today, university property was burnt. In view of our commitment to the safety of staff, students, and university property at the campus, it was necessary to evacuate the campus – including residences – with immediate effect. However, residential students are allowed to remain on campus until midday tomorrow (28 September 2016).

The university leadership again wants to emphasise its support for a national policy of free education for the poor and missing middle and stresses its support for peaceful protests on matters that are of concern to our students.
 
We further understand the frustration of many students and their parents/guardians at the closure of the campuses and the impact it has on academic staff, staff in the Support Services, our security personnel, teaching, learning, projects, assignments, lectures, tests, fieldwork, and the academic calendar in general, and commit to do all in our power to ensure the delivery of quality education to all our students under difficult circumstances.


Released by:
Lacea Loader (Director: Communication and Brand Management)
Telephone: +27 51 401 2584 | +27 83 645 2454
Email: news@ufs.ac.za | loaderl@ufs.ac.za
Fax: +27 51 444 6393

 

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