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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

State of our campuses: UFS closes campuses until Friday 28 October 2016 to readjust academic programme
2016-10-13

The senior leadership of the University of the Free State (UFS) has carefully analysed all the risks facing the university in the current national crisis in higher education, which includes the possibility of losing the academic year. The university management has been engaged in back-to-back meetings with the student leadership, South African Police Service (SAPS), and other stakeholders over the past two days in an attempt to ensure the safety of all parties, and normalise the academic functioning of the UFS.  Unfortunately, we have been unable to arrive at an agreement about the resumption of the academic year regardless of the timing of the government response to students’ demands. This is further complicated by the fact that the university has received notice of intention of an  interdict to reopen with immediate effect.

Taking all of this into account, the senior leadership of the UFS has decided as follows:

  1. The UFS will not be shutting down for the remainder of 2016. The Bloemfontein and South Campuses will, however, be shutting down from Thursday 13 October 2016 until Friday 28 October 2016. These two weeks will be used for crucial and complex arrangements to be put in place to readjust the academic calendar and ensure that all students can complete their studies.
  2. The academic arrangements are focused on organising alternative modes of delivery of our programmes to support student learning. Academics will be working on readjusting their course materials for this purpose.
  3. The Bloemfontein Campus and the South Campuses will be closed for undergraduate and honours students. Administrative and academic staff will be working, as well as master's and doctoral students.
  4. Students in residence will have to vacate their rooms by 12:00 on Saturday 15 October 2016. Students who need help in this regard must please contact +27 51 401 2001 or send an email to hotline@ufs.ac.za.
  5. Arrangements will be made to accommodate international, master's, and doctoral students.
  6. The specific information about academic programmes will be communicated to students by their respective faculties as it becomes available.

The senior leadership wants to restate its commitment to free education as well as its willingness to stand together with students and other public universities to impress on government the urgency to decide on a time frame for the roll-out of free higher education for the poor and missing middle. During these two weeks the UFS will meet with the leadership of Universities South Africa to coordinate collective action in this regard.

 Consistent with this commitment the UFS leadership will roll out a series of activities to inform and educate students and the general public on different models and experiences of providing free higher education. 

 The UFS is deeply concerned about the possible securitisation of our campus as a way of solving this crisis.

 The UFS condemns in the strongest terms violence as a methodology to achieve ends in the context of a democratic state.We are, as always, committed to providing quality education and a conducive environment for learning.

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